Encorafenib, as a targeted therapeutic drug, is mainly used to treat melanin placeholding and colorectal cell lesions. It provides patients with new therapeutic options by inhibiting the growth and spread of lesion cells. The use of drugs must follow strict dosage and precautions to ensure efficacy and safety.

What is the daily dose of Encorafenib?

The dose of Encorafenib varies according to the patient's specific condition and disease type. The following are the recommended doses for different patients.

Patients with Melanoma who are genetically mutated with BRAF-V600E or V600K that cannot be surgically removed or have been metastasized

For this type of patients, the recommended dose of Encorafenib is 450mg once a day (i.e., 6 75mg capsules), and it needs to be combined with bimetinib until the condition worsens or the patient suffers intolerable side effects. For specific medication instructions for bimetinib, please refer to its independent drug instructions.

CRC patients with BRAF-V600E gene mutation and metastasized

For this type of patients, it is recommended to use a daily dose of 300 mg (i.e. 4 75 mg capsules), which require coordinated treatment with cetuximab, and continue until the disease progresses or the patient experiences an unbearable toxic reaction. For detailed medication information about cetuximab, please refer to its exclusive medication instructions.

Understanding and following the correct dose is key to ensuring the efficacy and safety of Encorafenib.

What are the side effects of Encorafenib?

Encorafenib can cause a series of side effects during use, which vary by combination medication and individual differences.

Adverse reactions during treatment with Encorafenib and bimetinib

When Encorafenib was used in combination with bimetinib, the most common adverse reactions (≥25%) included fatigue, nausea, vomiting, abdominal pain, and joint pain.

Adverse reactions during treatment with Encorafenib combined with cetuximab

Common adverse reactions (≥25%) include fatigue, nausea, diarrhea, acne-like dermatitis, abdominal pain, decreased appetite, joint pain, and rash.

Understanding the side effects of Encorafenib helps patients and doctors better manage discomforts and risks during treatment.

How should we deal with symptoms such as nausea and vomiting when using Encorafenib?

Nausea and vomiting are common side effects when using Encorafenib. Here are some suggestions for dealing with these symptoms.

Dietary adjustment

If gastrointestinal problems occur, patients can try to adjust their diet and avoid spicy foods, greasy foods and a lot of fiber. It is recommended to eat multiple times to avoid overfilling and consult a doctor or professional nutritionist in advance.

Keep hydrated intake

Increasing moisture intake can help relieve discomfort caused by nausea and vomiting. However, you should avoid drinking plenty of water immediately after vomiting to avoid aggravating the symptoms.

Seek doctor advice

If the symptoms of nausea and vomiting are severe or cannot be relieved, the patient should report to the doctor in a timely manner and consult for further guidance. Doctors may adjust doses or give other treatment advice based on the patient's condition.

Dealing with symptoms such as nausea and vomiting caused by Encorafenib requires comprehensive consideration of the patient's specific situation and doctor's advice. Through reasonable dietary adjustments, maintaining hydration intake and seeking doctor advice in a timely manner, patients can effectively manage these side effects and improve their quality of life.