Pirtobrutinib is mainly used to treat relapsed or refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Patients need to strictly follow the doctor's instructions when using it, pay attention to the dosage, drug interactions and medication matters for special populations, so as to maximize the efficacy and reduce the risk of adverse reactions.

How to use Pirtobrutinib

The correct use of Pirtobrutinib is the key to ensuring efficacy. Patients need to take it strictly according to the recommended dose and method, and pay attention to possible adverse reactions.

Recommended dose and usage

The recommended dose of Pirtobrutinib is 200mg, taken orally once a day until the disease worsens or intolerable toxicity occurs. The tablets need to be swallowed whole and cannot be cut, crushed or chewed. The medication time should be fixed and can be taken with food or on an empty stomach. If you miss a dose for more than 12 hours, you do not need to make up for it, and take the next dose directly as planned.

Dosage form and properties

Pirtobrutinib is a tablet with two specifications: 50mg and 100mg. The 50mg tablet is a blue triangle with "Lilly 50" engraved on one side and "6902" engraved on the other side; the 100 mg tablet is a blue circle with "Lilly 100" and "7026" engraved on the other side. Patients can use these characteristics to identify the authenticity of the drug when taking it.

Adverse reaction monitoring

Common adverse reactions include fatigue, musculoskeletal pain, diarrhea, etc. In severe cases, neutropenia or bleeding may occur. Patients need to monitor blood routine and liver function regularly, and seek medical attention in time if abnormalities are found.

Rational use of Pirtobrutinib can effectively control the progression of the disease, but it is necessary to pay close attention to the body's reaction and adjust the treatment plan in time.

Drug interactions of Pirtobrutinib

Drug interactions may affect the efficacy of Pirtobrutinib or increase the risk of adverse reactions. Patients need to pay special attention to avoid co-administration of certain drugs.

Interaction with other drugs

Strong CYP3A inhibitors (such as clarithromycin) will increase the blood concentration of pirotbrutinib and increase the risk of toxicity, so co-administration should be avoided. If it must be used, the dose of pirotbrutinib should be reduced. Strong or moderate CYP3A inducers (such as rifampicin) will reduce its blood concentration and affect the efficacy, so co-administration should also be avoided.

Impact on sensitive drugs

Pirotbrutinib may inhibit enzymes such as CYP2C8 and CYP2C19, leading to increased blood concentrations of co-administered sensitive drugs (such as warfarin) and increased risk of adverse reactions. Patients should be cautious when using such drugs and adjust the dose if necessary.

Understanding drug interactions can help avoid potential risks. Patients should inform their doctors in detail of other drugs they are taking before taking the drug.

Use of pirotbrutinib in special populations

Special populations such as pregnant women, the elderly, or those with impaired liver and kidney function should pay special attention to adjusting the dose or monitoring indicators when using pirotbrutinib.

Pregnant and lactating women

Pregnant women may harm the fetus when using Pirtobrutinib, and they need to strictly prevent pregnancy until one week after stopping the drug. Lactating women should also stop breastfeeding to prevent the drug from affecting the baby through breast milk.

Elderly

Patients over 65 years old are more likely to have serious adverse reactions. They need to closely monitor their physical condition when taking the drug and adjust the dose if necessary.

Patients with hepatic and renal insufficiency

Patients with severe renal impairment need to reduce the dose, while patients with liver impairment usually do not need to adjust the dose, but they still need to check relevant indicators regularly.

Medication for special populations requires individualized treatment. Patients should develop appropriate treatment plans under the guidance of a doctor to balance efficacy and effectiveness.