Trabectedin (YONDELIS) is a chemotherapy drug for specific sarcomas with significant therapeutic effects. So, is there anything to pay attention to when using Trabectedin (YONDELIS)?

Is there anything to pay attention to when using Trabectedin(YONDELIS)?

Trabectedin is a powerful chemotherapy drug. During its treatment, it is necessary to strictly follow the doctor's instructions and pay attention to precautions in many aspects.

Usage and Dosage Adjustment

The recommended dose of Trabectedin is 1.5mg/m², which is infused through the central vein once every 21 days for 24 hours each time. For patients with moderate liver damage, the dose needs to be reduced to 0.9mg/m². Patients with severe liver damage are prohibited. During the medication process, if unacceptable toxic reactions occur, the dose needs to be adjusted or the drug needs to be stopped in time. At the same time, dexamethasone needs to be injected intravenously before each medication to prevent allergic reactions.

Adverse Reactions and Monitoring

Trabectedin may cause a variety of adverse reactions, including nausea, vomiting, fatigue, neutropenia, etc. Patients should undergo regular blood tests, liver function assessments, and electrocardiogram monitoring to promptly detect and treat abnormalities. If serious adverse reactions occur, such as liver failure, cardiomyopathy, rhabdomyolysis, etc., seek medical attention immediately.

When using trabectedin, patients should strictly follow the doctor's instructions, pay attention to usage and dosage, dose adjustment, and monitoring of adverse reactions to ensure the safety of treatment.

Drug interactions of trabectedin(YONDELIS)

Drug interactions may affect the efficacy and safety of trabectedin, so it is important to understand and avoid potential drug interactions.

Interactions with cytochrome CYP3A inhibitors

When trabectedin is used in combination with strong CYP3A inhibitors (such as ketoconazole, itraconazole, etc.), it may lead to increased blood concentrations of trabectedin and increase the risk of adverse reactions. Therefore, patients taking trabectedin should avoid using strong CYP3A inhibitors at the same time. If it must be used, the medication time should be adjusted under the guidance of a doctor to reduce interactions.

Interaction with cytochrome CYP3A inducers

When used in combination with strong CYP3A inducers (such as rifampicin, phenobarbital, etc.), the blood concentration of trabectedin may decrease, affecting the efficacy. Patients taking trabectedin should also avoid using strong CYP3A inducers at the same time.

Understanding and avoiding the interaction between trabectedin and potential drugs is the key to ensuring the therapeutic effect and reducing adverse reactions.

Use of trabectedin(YONDELIS) in special populations

Special populations (such as pregnant women, lactating women, children, elderly patients, etc.) should pay special attention to the efficacy of the drug when using trabectedin.

Pregnant and lactating women

Trabectedin has embryo-fetal toxicity and is contraindicated for pregnant women. Women of childbearing potential should take effective contraceptive measures during treatment and for at least 2 months after the last dose. Lactating women should stop breastfeeding during treatment.

Children and elderly patients

The safety and efficacy of trabectedin in children and elderly patients have not been confirmed. Children should use it with caution under the guidance of a doctor. There is no significant difference in the use of trabectedin in elderly patients, but the medication should also be adjusted according to individual conditions under the guidance of a doctor.

For special populations, the use of trabectedin should fully consider its medication safety, follow the doctor's advice, and ensure reasonable medication.