Caplacizumab was approved by the U.S. Food and Drug Administration (FDA) in 2019 for marketing under the trade name CABLIVI for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults. In addition, the drug was also approved by the European Union on September 3, 2018.

Indications of Caplacizumab

Understanding the indications of Caplacizumab is important for the correct use of the drug. This drug is specifically targeted at specific types of diseases and provides a new treatment option.

Acquired Thrombotic Thrombocytopenic Purpura (aTTP) in Adults

Caplacizumab is mainly used to treat adult aTTP by blocking the interaction between von Willebrand factor (vWF) and platelets, reducing vWF-mediated platelet adhesion and consumption. It is used in combination with plasma exchange and immunosuppressive therapy to significantly improve the patient's prognosis, shorten the recovery time of platelet count, and reduce the recurrence rate of the disease.

Combination therapy

In the treatment of aTTP, Caplacizumab is usually used in combination with other treatments such as plasma exchange and immunosuppressants to achieve the best therapeutic effect. This multi-faceted treatment method can effectively relieve symptoms and improve the quality of life of patients.

Understanding the indications of Caplacizumab can help doctors and patients jointly develop the most suitable treatment strategy to achieve better clinical outcomes.

Contraindications of Caplacizumab

Before using Caplacizumab, it is important to understand its contraindications. The following is a detailed introduction.

Situations with increased bleeding risk

Because Caplacizumab increases the risk of bleeding, patients with underlying coagulation diseases (such as hemophilia or other coagulation factor deficiencies) should use this drug with caution. Avoid using it with drugs that affect hemostasis and coagulation (such as antiplatelet drugs or anticoagulants).

Precautions for medication in special populations

Pregnant and lactating women should be cautious when using Caplacizumab because it may cause bleeding risks to the mother and fetus. For children and the elderly, there is currently limited research data on Caplacizumab, so special attention should be paid to individual differences when using it.

Fully aware of the contraindications of Caplacizumab can help doctors make safer choices when prescribing and guide patients to use drugs rationally.

Basic pharmacological effects of Caplacizumab

A deep understanding of the basic pharmacological mechanism of Caplacizumab is of great significance for the scientific and rational application of the drug. This not only helps to explain its efficacy, but also provides direction for future research.

Blocking vWF-platelet interaction

Caplacizumab effectively reduces vWF-mediated platelet adhesion and consumption by specifically blocking the interaction between vWF and platelets, thereby providing a new treatment approach for patients with aTTP. This mechanism makes Caplacizumab one of the key drugs for the treatment of aTTP.

Bioavailability and pharmacokinetic properties

The bioavailability of subcutaneous Caplacizumab is about 90%, and the maximum concentration can be observed 6 to 7 hours after subcutaneous administration once a day. This highly efficient absorption method ensures that the drug can take effect quickly in the body and maintain a stable blood drug concentration.

Understanding the basic pharmacological action of Caplacizumab can not only explain why it is effective for aTTP, but also provide a theoretical basis for exploring its application in other related diseases.