Nirogacestat is an innovative drug for specific lesions, and its price information and medication specifications are the focus of patients' attention. The following will introduce in detail the cost profile of the drug, contraindications and key precautions in use.

How much is OGSIVEO at the lowest price?

OGSIVEO has not yet been launched in China, and specific pricing information has not yet been made public. The drug was developed by SpringWorks Therapeutics in the United States, and the international market price may vary depending on the region and procurement channel.

Factors affecting price

Drug prices are affected by research and development costs, patent protection period and market demand. As the first γ-secretase inhibitor targeting specific gene mutations, OGSIVEO's innovativeness may make its price higher than traditional chemotherapy drugs. The unit price difference of different specifications (such as 50mg/150mg tablets) also needs to be taken into consideration.

Cost control suggestions

Patients can get free medication opportunities by participating in clinical trials, and some medical institutions provide charitable drug donation programs. It is recommended to choose a regular pharmacy when purchasing drugs overseas to avoid quality risks and economic losses caused by informal channels.

After understanding the price information, it is crucial to clarify the contraindications of medication to ensure safety. The following lists the contraindications of the drug.

Contraindications of Nirogacestat(OGSIVEO)

Although it has not been approved in China, according to international clinical trial data, the following groups need to strictly prohibit the use of Ogsiveo:

Absolute contraindications

It is contraindicated for those who are allergic to the ingredients of the drug, and pregnant and lactating women. It is contraindicated for patients with severe liver dysfunction (Child-Pugh C grade) because the drug is mainly metabolized by the liver, and impaired liver function will significantly increase the risk of poisoning.

Relative contraindications

Patients with moderate to severe renal insufficiency need to be carefully evaluated, and those with uncorrected electrolyte abnormalities need to suspend medication. Patients with uncontrolled hypertension or recent cardiovascular events (such as myocardial infarction) need to use it under the guidance of a specialist.

For the applicable population, standardized medication still requires attention to details. The following will detail the key precautions in use.

Precautions for OGSIVEO

To reduce the risk of adverse reactions and improve the treatment effect, patients need to pay special attention to the following matters:

Core monitoring indicators

Liver function (ALT/AST), electrolytes (phosphate, potassium), blood routine and ovarian function indicators should be tested regularly during medication. If diarrhea of grade 3 or above (≥7 times/day) occurs, seek medical attention immediately, and adjust the dose or interrupt treatment if necessary.

Management of special populations

Patients of childbearing age need to undergo pregnancy testing before treatment, and take double contraceptive measures during treatment and within 1 week after discontinuation of medication. For elderly patients (>75 years old), it is recommended that the starting dose be reduced to 100 mg/day and gradually adjusted according to tolerance.

OGSIVEO provides a new option for lesion treatment, but its price and medication specifications need to be fully understood by patients. It is recommended to communicate with the medical team regularly, report physical changes in a timely manner, and balance efficacy and safety. It is expected that this drug will benefit more domestic patients in the future and help the development of precise treatment of lesions.