Trabectedin is an anti-tumor drug developed by Johnson & Johnson (U.S.) for the treatment of specific sarcomas. It is indicated for patients with unresectable or metastatic liposarcoma or leiomyosarcoma. For many patients, questions such as whether the drug can be purchased in China, its specific usage, dosage, and therapeutic effects are of great concern. So, can Trabectedin be bought in China?

Can Trabectedin be Bought in China?

According to the latest information, Trabectedin has not yet been launched in China. This means that patients cannot purchase the drug directly from pharmacies or hospitals in China.

Overseas Purchase Channels

Although Trabectedin is not available in China, patients can still purchase it through overseas channels. Some professional overseas medical institutions or pharmacies may offer sales services for Trabectedin. However, overseas purchase involves a series of issues such as cross-border logistics, payment security, and identification of the authenticity of the drug. Therefore, patients must carefully select purchase channels.

Legality and Recommendations

When considering purchasing Trabectedin overseas, patients also need to pay attention to the restrictions of local laws and regulations. Some countries and regions may have strict management regulations on imported drugs, so patients must ensure the legality of purchasing and carrying the drug. It is recommended that patients consult professional doctors or pharmacists before purchasing to understand the applicability, usage, dosage, and potential risks of Trabectedin.

Usage and Dosage of Trabectedin

The recommended dose of Trabectedin is 1.5 mg/m², administered via central venous infusion once every 21 days, with each infusion lasting for 24 hours.

Dosage Adjustment for Special Populations

For patients with moderate hepatic impairment, the recommended dose should be reduced to 0.9 mg/m². Trabectedin is contraindicated in patients with severe hepatic impairment. Doctors may further adjust the dose based on the patient's specific condition and the occurrence of adverse reactions.

Preparation and Precautions Before Medication

Before each use of Trabectedin, patients need to undergo a series of preparatory work, including assessment of liver function, neutrophil count, and creatine phosphokinase levels. It is also important to avoid concurrent use with other drugs to prevent potential drug-drug interactions. During the infusion process, the patient's vital signs and the occurrence of adverse reactions should be closely monitored.

Therapeutic Efficacy of Trabectedin

Clinical trial data show that Trabectedin exhibits certain efficacy in the treatment of the aforementioned indications, as it can prolong the survival time of patients and improve their quality of life.

Mechanism of Action and Targets

The mechanism of action of Trabectedin involves binding to guanine residues in the minor groove of DNA, leading to double-strand DNA breaks and subsequent cell apoptosis. This unique mechanism of action gives Trabectedin unique advantages in the treatment of certain sarcomas.

Adverse Reactions and Management

Despite its certain therapeutic effects, Trabectedin may also cause a series of adverse reactions, such as nausea, vomiting, fatigue, and neutropenia. For patients who experience adverse reactions, doctors need to adjust the medication regimen or provide corresponding treatment based on the specific situation.

When using Trabectedin, patients must follow the guidance of doctors, and understand the drug's usage, dosage, indications, mechanism of action, and potential risks. They also need to pay attention to the drug's therapeutic effects and adverse reactions, so that the treatment plan can be adjusted in a timely manner if necessary.