Trabectedin primarily targets tumors that are no longer sensitive to conventional chemotherapy drugs or have developed drug resistance, such as liposarcoma and leiomyosarcoma. As an innovative therapeutic agent for specific tumor types, its therapeutic effects have garnered widespread attention and validation in clinical practice, enabling it to prolong patients' survival and improve their quality of life.

How Effective is Trabectedin in Treatment?

Trabectedin exerts its action by targeting guanine residues in the minor groove of DNA, thereby interfering with the DNA replication and transcription processes of tumor cells, ultimately leading to the death of these cells.

Indications and Efficacy Evaluation

Trabectedin is mainly used for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma in patients who have previously received anthracycline-based therapy. For such patients, treatment options are very limited due to prior failures with multiple chemotherapy regimens. In clinical trials, trabectedin has demonstrated significant efficacy against specific tumor types, capable of extending patients' survival time and enhancing their quality of life.

Patient Feedback and Case Sharing

After receiving trabectedin treatment, some patients have experienced a significant reduction in tumor size, with their condition effectively controlled. The therapeutic effect may vary among different patients due to individual differences. However, in general, trabectedin provides a new treatment option for patients who are no longer sensitive to traditional chemotherapy drugs.

Dietary Precautions for Trabectedin Treatment

Each patient may have different specific conditions and reactions, so personalized principles should be followed when adjusting the diet.

Nutritional Balance and Immunity Enhancement

During trabectedin treatment, patients need to pay special attention to maintaining a balanced diet. A good nutritional status helps enhance the patient's immunity and improve the body's tolerance, thereby better coping with the side effects of chemotherapy. It is recommended that patients consume more foods rich in protein, vitamins, and minerals, such as lean meat, fish, fresh vegetables, and fruits.

Avoid Stimulating Foods

During the treatment period, patients should try to avoid consuming stimulating foods, such as spicy, greasy, and cold foods. These foods may increase the burden on the gastrointestinal tract, exacerbating symptoms such as indigestion and diarrhea. Patients should also avoid bad habits like drinking alcohol and smoking, as these may have a negative impact on the treatment effect.

Therapeutic effects are not achieved overnight; patients need to pay attention to coordination and conditioning in various aspects during the treatment period. In terms of diet, patients should focus on nutritional balance, avoid stimulating foods, and make personalized adjustments based on their specific conditions.