Isavuconazonium Sulfate Capsules (Cresemba) is a broad-spectrum triazole antifungal medication. Its active ingredient is isavuconazole, which exerts antifungal effects by inhibiting the synthesis of ergosterol in fungal cell membranes.

Indications of Isavuconazonium Sulfate Capsules (Cresemba)

Invasive Aspergillosis

Applicable to pediatric patients aged 6 years and above with a body weight of ≥ 16 kg, as well as adult patients. It has definite efficacy especially for immunocompromised patients (e.g., those with hematologic malignancies, post-hematopoietic stem cell transplantation) complicated with infections caused by Aspergillus species (such as Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger).

Before treatment, it is recommended to confirm the pathogen through histopathology or microbial culture. However, empirical treatment can be initiated when there is a high clinical suspicion of infection.

Invasive Mucormycosis

For infections caused by fungi of the order Mucorales (such as Rhizopus oryzae, Mucor species), it is applicable to patients who meet the same age and weight criteria.

Its efficacy is supported by open-label clinical trials, and it can be used as first-line treatment or an alternative option when other antifungal drugs are intolerable or ineffective.

Specifications and Properties of Isavuconazonium Sulfate Capsules (Cresemba)

Dosage Form and Content

74.5mg Capsule: Each capsule contains 74.5mg of isavuconazonium sulfate (equivalent to 40mg of isavuconazole). It is an opaque capsule with a Swedish orange-red (reddish-brown) body printed with the black Astellas logo, and a cap of the same color marked with the black character "557".

186mg Capsule: Each capsule contains 186mg of isavuconazonium sulfate (equivalent to 100mg of isavuconazole). It is an opaque elongated capsule with a body of the same color as the 74.5mg specification, and a white cap printed with the black character "766".

Excipient Components

It contains inactive ingredients such as microcrystalline cellulose, silicon dioxide, and stearic acid. The capsule shell contains hypromellose, iron oxide colorants, and shellac.

Storage Methods of Isavuconazonium Sulfate Capsules (Cresemba)

Environmental Requirements

Store at room temperature of 20°C ~ 25°C (68°F ~ 77°F). Short-term exposure to 15°C ~ 30°C (59°F ~ 86°F) is allowed.

Must be kept in the original aluminum foil blister packaging (with built-in desiccant) to avoid moisture.

Precautions for Use

When opening the blister packaging, only puncture the recess where the capsule is located, and do not touch the desiccant bag.

Discard expired or unused medications to prevent accidental access by children.