Repotrectinib (Augtyro) is a next-generation kinase inhibitor and an important targeted medication for the treatment of ROS1-positive non-small cell lung cancer (NSCLC) and NTRK gene fusion-positive solid tumors.
How to Purchase Repotrectinib (Augtyro)
Overseas Purchase
Patients may choose to consult and purchase repotrectinib at hospital pharmacies or authorized retail pharmacies in countries or regions where the medication has been launched.
Since drug prices may be affected by factors such as regional differences and exchange rate fluctuations, patients need to make a budget and plan in advance before purchasing.
Purchase via Medical Service Institutions
Patients may consult domestic overseas medical service institutions that cooperate with international pharmacies or pharmaceutical companies.
These institutions can usually provide legal import channels and offer professional consultation and guidance.
Precautions for Repotrectinib (Augtyro)
Defined Indication Scope
Locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) in adults.
NTRK gene fusion-positive solid tumors in adult and pediatric patients aged 12 years and older.
Patient Screening Requirements
NSCLC patients must undergo testing for ROS1 rearrangement in tumor specimens.
Solid tumor patients must undergo testing for NTRK1/2/3 rearrangements.
For patients with secretory breast carcinoma or breast cancer-like secretory carcinoma, treatment may be considered without confirming NTRK rearrangement.
Important Pre-Treatment Examinations
Liver function tests (including bilirubin).
Uric acid level testing.
Medications Prohibited for Concomitant Use
Strong and moderate CYP3A inhibitors.
P-gp inhibitors.
Strong and moderate CYP3A inducers.
Certain CYP3A substrates.
Hormonal contraceptives.
Key Methods to Identify the Authenticity of Repotrectinib (Augtyro)
Verify Packaging Characteristics
40 mg strength: Available in bottles of 60 capsules or 120 capsules.
160 mg strength: Available in bottles of 14 capsules or 60 capsules.
Carefully verify the accuracy of the drug approval number and manufacturer information.
Confirm Capsule Markings
40 mg capsules: White opaque, Size 0 hard-shell capsules. The contents are white to off-white powder, which may be in the form of a plug. The cap is printed with blue text "REP40".
160 mg capsules: Blue opaque, Size 0 hard-shell capsules. The contents are white to off-white powder, which may be in the form of a plug. The cap is printed with white text "REP160".
