pemazyre(pemigatinib) Side Effects

Pemigatinib is an effective drug used for the treatment of cholangiocarcinoma and myeloid/lymphoid neoplasms. However, the use of any drug may be accompanied by certain side effects. This article aims to introduce the common side effects of pemigatinib, so as to help patients and physicians better understand and manage potential adverse reactions. Understanding the side effects of pemigatinib enables patients to take appropriate measures in a timely manner, ensuring the smooth progress of drug treatment while alleviating or preventing the impact of side effects on quality of life.

Side Effects of Pemigatinib

1. Cholangiocarcinoma

The most common (≥20%) adverse reactions are hyperphosphatemia, alopecia, diarrhea, nail toxicity, fatigue, dysphagia, nausea, constipation, stomatitis, dry eye, xerostomia, decreased appetite, vomiting, arthralgia, abdominal pain, hypophosphatemia, back pain, and dry skin.

2. Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement

The most common (≥20%) adverse reactions are hyperphosphatemia, nail toxicity, alopecia, stomatitis, diarrhea, dry eye, fatigue, rash, abdominal pain, anemia, constipation, xerostomia, epistaxis, serous retinal detachment, extremity pain, decreased appetite, dry skin, dyspepsia, back pain, nausea, blurred vision, peripheral edema, and dizziness.