How should I use Agamree(Vamorolone)?

AGAMREE dosing varies by hepatic function and concomitant drug use, with gradual tapering required for discontinuation.

Dosing Guidelines and Modifications

AGAMREE is administered orally once daily with food. The standard dosage is 6 mg/kg (max 300 mg/day) for patients ≥2 years with DMD. For mild-to-moderate hepatic impairment (Child-Pugh A/B), dosage reduces to 2 mg/kg (max 100 mg/day). When co-administered with strong CYP3A4 inhibitors (e.g., itraconazole), dosage is adjusted to 4 mg/kg (max 200 mg/day). Abrupt discontinuation after >1 week of use is contraindicated; gradual tapering is required to mitigate adrenal insufficiency. Pediatric patients switching from other corticosteroids can transition directly to AGAMREE 6 mg/kg. Suspension preparation involves shaking for 30 seconds, using provided oral syringes, and discarding unused portions after 3 months.