How should I use Defitelio(Defibrotide)?

Defitelio should be administered at a dose of 6.25 mg/kg every 6 hours via a 2-hour intravenous infusion, with a minimum treatment duration of 21 days.

Dosage Instructions

Defitelio (defibrotide sodium) is to be administered intravenously at a dose of 6.25 mg/kg every 6 hours, delivered over a 2-hour infusion period. This regimen is recommended for a minimum duration of 21 days. If signs and symptoms of hepatic veno-occlusive disease (VOD) have not resolved after this initial period, treatment should continue until resolution is achieved. The drug comes in a vial with a concentration of 200 mg/2.5 mL (80 mg/mL). It is important to closely monitor patients during administration for any signs of adverse reactions or complications.