How should I use Daxas(Roflumilast‌)?

The recommended dosing involves a 4-week titration period starting with a lower dose before advancing to the maintenance dose to improve tolerability.

Dosage and Administration

The maintenance therapeutic dose of DALIRESP is one 500 mcg tablet taken orally once daily, which can be administered with or without food. To improve tolerability and potentially reduce early treatment discontinuation in some patients, a dose titration strategy is recommended. This involves initiating treatment with a 250 mcg tablet once daily for the first 4 weeks, after which the dose is increased to the effective 500 mcg once-daily maintenance dose. The 250 mcg strength is intended solely for this initial titration period and is not an effective standalone dose.