How should I use Vonjo(Pacritinib)?

The standard dosing involves twice-daily oral administration, with specific adjustments required for certain patient populations and adverse reactions.

How should I use Vonjo(Pacritinib)?

The recommended dosage of VONJO is 200 mg taken orally twice daily, which can be administered with or without food. Capsules must be swallowed whole. For patients with severe hepatic impairment (Child-Pugh C), the initial dosage should be reduced to 100 mg twice daily, with a potential increase to the standard dose after 12 weeks if there is no efficacy and safety concerns permit. Dose interruptions, reductions, or discontinuations are mandated for managing adverse events such as significant hemorrhage, diarrhea, thrombocytopenia, and QT interval prolongation.