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Cosentyx(Secukinumab)
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.
Cosentyx(Secukinumab) Instructions:Uses,Dosage, Side Effects
COSENTYX is a recombinant human monoclonal IgG1/κ antibody that selectively binds to interleukin-17A (IL-17A), inhibiting its interaction with the IL-17 receptor. IL-17A is a proinflammatory cytokine implicated in the pathogenesis of several autoimmune and inflammatory disorders. By neutralizing IL-17A, COSENTYX reduces downstream inflammatory signaling, thereby ameliorating disease activity in conditions such as psoriasis, psoriatic arthritis, and axial spondyloarthritis.
COSENTYX is available for subcutaneous or intravenous administration, with dosing regimens tailored to specific indications. Subcutaneous formulations include weight-based dosing for pediatric populations and fixed doses for adults, while intravenous use is reserved for adults with PsA, AS, or nr-axSpA. Common adverse reactions include nasopharyngitis, upper respiratory tract infections, and diarrhea.
COSENTYX is indicated for the treatment of:
1. Plaque Psoriasis (PsO): Moderate to severe in patients aged ≥6 years who are candidates for systemic therapy or phototherapy.
2. Psoriatic Arthritis (PsA): Active, in patients aged ≥2 years.
3. Ankylosing Spondylitis (AS): Active, in adults.
4. Non-radiographic Axial Spondyloarthritis (nr-axSpA): Active, with objective signs of inflammation in adults.
5. Enthesitis-Related Arthritis (ERA): Active, in pediatric patients aged ≥4 years.
6. Hidradenitis Suppurativa (HS): Moderate to severe, in adults.
Vaccination & TB Screening: Complete age-appropriate immunizations and screen for tuberculosis before initiation.
1. Subcutaneous Dosing:
1.1 PsO Adults: 300 mg at Weeks 0, 1, 2, 3, 4, then every 4 weeks (150 mg may be considered).
1.2 PsO Pediatrics (≥6 years):<50 kg: 75 mg;≥50 kg: 150 mg.
1.3 PsA Adults:With PsO: Follow PsO dosing;Without PsO: 150 mg with or without loading dose; may increase to 300 mg if needed.
1.4 PsA Pediatrics (≥2 years):15–<50 kg: 75 mg;≥50 kg: 150 mg.
1.5 AS and nr-axSpA Adults:150 mg with or without loading dose; may increase to 300 mg.
1.6 ERA Pediatrics (≥4 years):15–<50 kg: 75 mg;≥50 kg: 150 mg.
1.7 HS Adults: 300 mg at Weeks 0–4, then every 4 weeks. If inadequate response, increase to every 2 weeks.
2. Intravenous Dosing (AS, PsA, nr-axSpA):
2.1 With loading: 6 mg/kg IV at Week 0, then 1.75 mg/kg every 4 weeks (max 300 mg/infusion).
2.2 Without loading: 1.75 mg/kg every 4 weeks (max 300 mg/infusion).
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