Ticagrelor (Brilinta) is a novel antiplatelet agent that holds an important position in the treatment of cardiovascular diseases.
What is Ticagrelor (Brilinta)?
Acute Coronary Syndrome (ACS)
Indicated for patients with unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).
Limited to cases where dual antiplatelet therapy with aspirin is applicable and other P2Y12 antagonists are difficult to use.
Old Myocardial Infarction
For patients with at least one high-risk factor for atherothrombosis.
Risk factors include: age ≥ 65 years, diabetes mellitus requiring pharmacotherapy, history of multiple myocardial infarctions, angiographically confirmed multi-vessel disease, or non-end-stage chronic kidney disease.
Unique Mechanism of Action
Selectively blocks the binding of adenosine diphosphate (ADP) to P2Y12 receptors, inhibiting platelet activation.
Simultaneously inhibits the equilibrative nucleoside transporter 1 (ENT-1), increasing local adenosine concentration and enhancing vascular protective effects.
Specifications and Properties of Ticagrelor (Brilinta)
Detailed Parameters of the 60 mg Strength
Dosage Form: Round, film-coated tablets, very pale yellowish-red.
Dimensions: Approximately 8.1 mm in diameter and 3.8 mm in thickness.
Weight: Approximately 0.21 g.
Identification Code: 60T.
Packaging: 140-tablet pack [14 tablets (PTP) × 10 blisters].
Detailed Parameters of the 90 mg Strength
Dosage Form: Round, film-coated tablets, pale yellow.
Dimensions: Approximately 9.2 mm in diameter and 4.6 mm in thickness.
Weight: Approximately 0.31 g.
Identification Code: 90T.
Active Ingredients of 60 mg Tablets
Ticagrelor 60 mg.
Excipients: D-mannitol, calcium hydrogen phosphate hydrate, sodium carboxymethyl starch, hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol 400, iron oxide black, iron oxide red.
Active Ingredients of 90 mg Tablets
Ticagrelor 90 mg.
Excipients: D-mannitol, calcium hydrogen phosphate hydrate, sodium carboxymethyl starch, hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide, talc, polyethylene glycol 400, iron oxide yellow.
Storage Conditions of Ticagrelor (Brilinta)
Standard Storage Specifications
Ticagrelor should be stored at room temperature, away from high temperature, moisture, and direct sunlight.
Shelf Life
Shelf Life: 3 years.
Special Precautions
PTP (Press-Through Package) Warning: Patients must be instructed to remove the tablets from the PTP aluminum blister before administration.
Accidental ingestion of the PTP blister may cause esophageal mucosal penetration, which can lead to complications such as mediastinitis in severe cases.
