Mavacamten (Camzyos) is an oral cardiac myosin inhibitor that received its first approval in the United States in 2022. As an innovative therapy, it offers a new treatment direction for patients with specific types of heart disease.

What Are the Indications for Mavacamten (Camzyos)?

Core Indications

Mavacamten is indicated for the treatment of symptomatic adults with obstructive hypertrophic cardiomyopathy (HCM) classified as New York Heart Association (NYHA) Functional Class II–III, aiming to improve patients' functional capacity and symptoms.

Target Population: This drug is not suitable for all HCM patients, but specifically for adult patients with left ventricular outflow tract obstruction and accompanying symptoms (such as dyspnea, chest pain, fatigue, syncope or near-syncope).

Disease Stage: It is mainly intended for patients with NYHA Class II (mild limitation of physical activity) or Class III (marked limitation of physical activity) heart function, to relieve symptoms and enhance exercise tolerance.

Dosage Forms, Specifications and Appearance Characteristics of Mavacamten (Camzyos)

Dosage Forms and Specifications

This product is available as hard capsules, with the following specifications: 2.5 mg, 5 mg, 10 mg, and 15 mg.

All capsules are opaque. The capsule body is printed with the word "Mava", and the capsule cap is printed with the corresponding specification (in milligrams). Different cap colors are used for distinction to facilitate identification.

Appearance Characteristics

2.5 mg: Light purple capsule cap.

5 mg: Yellow capsule cap.

10 mg: Pink capsule cap.

15 mg: Gray capsule cap.

Composition

The capsule contents are white to off-white powder.

The active ingredient is mavacamten. The excipients include croscarmellose sodium, hypromellose, magnesium stearate (non-bovine source), mannitol, and silicon dioxide.

Storage Methods for Mavacamten (Camzyos)

Storage Conditions

Temperature: Store at controlled room temperature between 20°C and 25°C (68°F and 77°F). Short-term transportation or temporary storage at a temperature range of 15°C to 30°C (59°F to 86°F) is permitted.

Environment: Keep the capsules in the original packaging bottle, and protect them from moisture, light and excessive heat. Do not store the medicine in the bathroom or near damp places or heat sources such as sinks and radiators.

Important Precautions

Safe Storage: Always store the medicine in a place out of children's reach and sight to prevent accidental ingestion. Tragic deaths in infants due to accidental ingestion have been reported.

Integrity: Swallow the capsules whole. Do not break, crush or chew the capsules.

Expired Disposal: Do not use the medicine beyond the expiration date. When discarding unused or expired medicine, follow local regulations or dispose of it through a drug take-back program. Do not flush it directly down the toilet or pour it into the drain.