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Is Tazemetostat generic drug effective?
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Article source: Seagull Pharmacy
Jun 20, 2025

Tazemetostat is a targeted drug used to treat epithelioid sarcoma and follicular lymphoma. It blocks the growth and diffusion of lesion cells by inhibiting the activity of EZH2 methyltransferase. Due to the high price of original drugs, many patients pay attention to the effects of generic drugs.

Is Tazemetostat generic drug effective?

Tazemetostat's generic drugs are similar to the original drugs in terms of efficacy and safety, but the price is more affordable. The production process and ingredients of generic drugs are basically the same as those of the original drugs, which can effectively inhibit the activity of EZH2 methyltransferase and help control the growth and spread of lesions.

The efficacy of generic drugs

Tazemetostat's generic drug showed similar efficacy in clinical trials as the original drug. Generic drugs provide patients with affordable treatment options by inhibiting the activity of EZH2 methyltransferase and blocking the growth and spread of lesion cells.

Safety of generic drugs

Tazemetostat's generic drug is also similar to the original drug in terms of safety. Common side effects include fatigue, nausea, and decreased appetite. Patients should monitor adverse reactions regularly during use and adjust the dose according to the doctor's advice.

Generic drugs are similar to original drugs in terms of efficacy and safety, but the prices are more affordable. Next, we will introduce the difference between generic Tazemetostat and original drug.

The difference between generic drugs for Tazemetostat and original drugs

Tazemetostat's generic drugs and original drugs are basically the same in terms of ingredients, efficacy and safety, but the prices are different from those of the manufacturer. Generic drugs are usually cheaper and are suitable for patients with limited economic conditions.

Price difference

The original drug of Tazemetostat is relatively expensive, with a reference price of 200mg*240 tablets, which is about US$7,213. The price of generic drugs is relatively low. 

Manufacturer

Tazemetostat's original drug was developed by Epizyme in the United States, while generic drugs were produced by manufacturers such as Lucius in Laos and Big Bear in Laos. The production process and ingredients of generic drugs are basically the same as those of the original drugs and can provide similar therapeutic effects.

Generic drugs and original drugs are basically the same in terms of ingredients and efficacy, but the prices are different from those of the manufacturer. Next, we will introduce whether long-term use of Tazemetostat will cause drug resistance.

Will drug resistance appear after long-term use of Tazemetostat?

Tazemetostat may develop drug resistance during long-term use. The production of drug resistance is related to genetic mutations in lesion cells and changes in drug action mechanisms. Patients should monitor their condition regularly during use and adjust the treatment plan if necessary.

The creation of drug resistance

Tazemetostat inhibits the activity of EZH2 methyltransferase and blocks the growth and spread of lesion cells. Long-term use may lead to drug resistance in lesion cells and affects the therapeutic effect of the drug. Patients should undergo genetic testing regularly to detect drug resistance in a timely manner.

Strategies to deal with drug resistance

If the patient develops resistance during Tazemetostat, the doctor may adjust the treatment plan, such as the use of other targeted drugs or chemotherapy drugs in combination. Patients should strictly follow the doctor's instructions and review them regularly.

Tazemetostat is a prescription drug. Patients should strictly follow medical advice when using it, monitor the condition regularly, and prevent possible drug resistance and serious adverse reactions.

Note: For internal discussion among medical personnel only. For specific medication, please consult the attending physician. Drug information may change over time. For the latest information, we recommend adding a medical consultant or consulting for free online.
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