The main ingredient of Filspari is Sparsentan, which acts on ETAR and AT1R, can reduce the level of proteinuria in patients, and has the "orphan drug title" for the treatment of IgA nephropathy.

What kinds of diseases is Sparsentan(Filspari) suitable for?

Sparsentan has the effect of antagonizing type A endothelin receptor (ETAR) and angiotensin type II type 1 receptor (AT1R), which is suitable for adult patients with primary immunoglobulin A nephropathy (IgAN), and Sparsentan achieves the purpose of treating diseases by antagonizing type A endothelin receptor (ETAR) and angiotensin type II type 1 receptor (AT1R).

Sepasentan is not currently marketed in China, patients can consult and purchase through the overseas medical consulting service platform if necessary, pay attention to the medication according to the doctor's medication guidance and treatment plan when purchasing and using, follow the doctor's instructions, and if there are any adverse reactions in the process of medication, it is necessary to communicate with the doctor in time so as to adjust the medication regimen and dosage.

Recommended dosage of Sparsentan(Filspari)

The following is the recommended dosage of sparsentan under normal circumstances, which is for the patient's reference only, and the specific dosage and dose adjustment need to be carried out according to the specific situation of the patient, during the treatment process, the patient should follow the doctor's advice, and regularly review and evaluate.

Starting dose

For patients starting Sparsentan, the recommended starting dose is 200mg orally once daily. The purpose of this dose is to help the patient gradually adjust to the drug and observe how well it can tolerate it.

Dose adjustment

On the 14th day of medication, the doctor will adjust the dose to 400mg once a day according to the patient's tolerance and response to efficacy.

Restart after the interruption of the medication process

When patients need to restart treatment after discontinuation of Sparsentan, it is recommended to start with a dose of 200mg once daily and gradually increase the dose to 400 mg once daily after 14 days. This can help reduce adverse effects due to a sudden increase in medications.

When purchasing medicines, it is important to ensure that the purchase channel is regular. It is recommended to choose a reputable and regular pharmacy or medical institution to purchase to ensure the quality of the medicine. Avoid buying medicines from unknown sources to avoid encountering counterfeit and shoddy products that can harm your health. Choose formal channels carefully.