Rucaparib is an orally active and potent inhibitor of polyadenosine diphosphate ribose polymerase (PARP). It is suitable for maintenance therapy of BRCA-mutated recurrent ovarian disease and BRCA-mutated metastatic castration-resistant prostate disease. The following will elaborate on the contraindications of Rucaparib, side effects and interactions.

What are the contraindications to the use of Rucaparib?

As a professional medical drug, Rucaparib needs to be followed with certain precautions during use.

Potential Risks

Patients treated with Rucaparib are at risk for MDS/AML and should be fully informed and informed of this risk before using Rucaparib.

Avoid use until hematologic toxicity has resumed

Before starting a new drug therapy, it is important to ensure that the patient's blood tests, such as blood counts, have returned to normal or acceptable ranges.

Complete blood count monitoring at baseline

Useful in identifying underlying hematologic abnormalities to avoid initiating treatment in inappropriate circumstances.

Now that we know what are the contraindications to use, let's take a look at the side effects.

What are the side effects of Rucaparib?

Rucaparib has side effects, like any drug, which manifest themselves in the following ways.

Digestive system reactions

Nausea, vomiting, diarrhea, decreased appetite, indigestion

Hematologic reactions

Anemia, elevated AST (aspartate aminotransferase)/ALT (alanine aminotransferase), thrombocytopenia, neutropenia, leukopenia

Skin reactions

Photosensitivity reactions, rashes

other

Fatigue, weakness, constipation

Now that we've learned about the side effects, let's take a look at the interactions.

Rucaparib's interactions?

There are many aspects to consider regarding drug interactions with Rucaparib, and the following is a detailed summary of drug interactions:

with gastric acid suppressants

Proton pump inhibitors (eg, omeprazole) and H2 receptor antagonists (eg, ranitidine), as well as some alkaline drugs (eg, antipyrine hydrochloride), may reduce Rucaparib absorption.

with liver enzyme inducers

For example, rifampicin and carbamazepine can accelerate the metabolism of Rucaparib and reduce its concentration in the body, thereby reducing its efficacy.

with liver enzyme inhibitors

Barbiturates and verapamil, for example, can inhibit the metabolism of Rucaparib and increase its concentration in the body, which may lead to an increase in the adverse effects of the drug.

with antibiotics

Quinolone antibiotics and Rucaparib interfere with each other to reduce plasma concentrations of Rucaparib.

with anticoagulant drugs

Concomitant use of Rucaparib, such as warfarin, may increase the risk of bleeding.

These interactions may affect the efficacy and safety of medications, so it is important to follow your doctor's advice and pay close attention to drug reactions and side effects when using Rucaparib.