Quizartinib (Vanflyta) is indicated for the treatment of newly diagnosed adult patients with acute myeloid disease (AML) who are positive for FLT3 internal tandem duplication (ITD) as detected by an FDA-approved test method. So, what are the precautions when taking Quizartinib (Vanflyta)?

Precautions when taking Quizartinib

During the use of Quizartinib, patients need to pay attention to the following aspects to avoid adverse effects.

ECG monitoring

QT interval prolongation is an important adverse reaction of Quizartinib. Therefore, patients should undergo an ECG before starting medication and before each dose adjustment to ensure that the QTcF value does not exceed 450 milliseconds. ECGs should also be performed regularly during treatment, especially once a week in the first two weeks of medication, and once a month thereafter.

Routine blood tests

Quizartinib may cause bone marrow suppression and bleeding. Before starting medication and during medication, patients should undergo regular routine blood tests and closely observe changes in blood indicators.

Drug interactions

Quizatinib may interact with other drugs, especially strong CYP3A inducers. These drugs may reduce the blood concentration of quizatinib and affect the efficacy. Patients should avoid using these drugs during the use of quizatinib. If necessary, the doctor will adjust the dose of quizatinib.

When taking quizatinib, patients need to pay close attention to the electrocardiogram and blood routine indicators to avoid interactions with other drugs to ensure the safety and effectiveness of the drug.

Taboo foods during treatment with quizatinib

During treatment, the patient's dietary management is equally important. The following are some taboo foods that need to be avoided.

Irritating foods

Patients should try to avoid spicy, greasy, raw and cold foods to avoid increasing the gastrointestinal burden or causing adverse reactions.

Allergic foods

For foods that are known to cause allergies, patients should be cautious in eating them to avoid allergic reactions and affecting the treatment effect.

Nutritional imbalance

Patients should maintain a balanced nutrition and avoid over-reliance on a certain food or nutrient to avoid nutritional imbalance and affect the body's normal metabolism and immune function.

During the treatment with Quizartinib, patients should avoid consuming irritating foods and allergic foods and maintain a balanced nutrition to support the body's normal metabolism and immune function and improve the treatment effect.