lemborexant is an innovative insomnia treatment drug that provides a new treatment option for adult insomnia patients. This article will introduce in detail the use of lemborexant, special population medication considerations and precautions, aiming to help patients better understand and apply this drug.

How to use lemborexant

lemborexant is mainly used to treat adult insomnia patients characterized by difficulty in starting or maintaining sleep. Correct use of lemborexant is the key to therapeutic effect.

Dosage information

The recommended starting dose of lemborexant is 5 mg, once a night, which should be taken before bedtime and at least 7 hours before the planned wake-up time. If the clinical response is good and tolerable, the dose can be gradually increased to the maximum recommended dose of 10 mg. Importantly, taking it with or shortly after a meal may affect the time to fall asleep, which is recommended to avoid.

Drug interactions and dose adjustments

When using lemborexant, special attention should be paid to interactions with CYP3A inhibitors or inducers. Strong or moderate CYP3A inhibitors should be avoided with lemborexant, and when used with weak CYP3A inhibitors, the maximum dose should be limited to 5 mg. For patients with impaired liver function, the maximum dose for moderate impairment is 5 mg, while it is not recommended for patients with severe liver impairment.

The use of lemborexant should strictly follow the dosage guidelines, taking into account drug interactions and individual liver function status.

Use of lemborexant in special populations

Special populations need to pay extra attention when using lemborexant.

Pregnant and lactating women

There is insufficient data on the use of lemborexant in pregnant women, and it is recommended to use it with caution under the guidance of a doctor. The effect of lemborexant on breastfed infants in lactating women is also unclear, and it also needs to be used under the guidance of a doctor.

Elderly and pediatric patients

When elderly patients use lemborexant, they should be cautious when taking a dose greater than 5 mg because it may increase the risk of drowsiness and sleepiness, especially the risk of falling. The effectiveness of pediatric patients has not been confirmed, so it is not recommended.

Patients with renal and hepatic impairment

Patients with mild to severe renal impairment do not need to adjust the dose when using lemborexant, but patients with severe renal impairment may face an increased risk of drowsiness. For patients with hepatic impairment, moderate impairment requires dose restriction, while severe impairment is not recommended.

Special populations need to adjust the dose according to individual conditions or use it under the guidance of a doctor when using lemborexant.

Precautions for lemborexant

Understanding and following the precautions for lemborexant is particularly important for the treatment effect.

Central nervous system depressant effects

Central nervous system depressant effects may occur after the use of lemborexant, leading to symptoms such as daytime impairment, sleep paralysis, and hypnotic hallucinations. Patients are advised to avoid activities that require high alertness during use.

Drug interactions and avoidance of alcohol

In addition to known CYP3A inhibitors or inducers, patients should also avoid using other drugs that may interact. Drinking alcohol may exacerbate the central depressant effects of lemborexant and should be strictly avoided.

lemborexant is an innovative drug for the treatment of insomnia. Through proper use, medication guidance for special populations and strict compliance with precautions, it can improve the sleep quality and quality of life of adult insomnia patients. During use, be sure to follow the doctor's instructions and have regular health checks.