Lemborexant (Dayvigo) is an orexin receptor antagonist used for the treatment of insomnia in adults. Like other medications, it may be accompanied by certain side effects, which need to be alleviated through rational medication use and daily precautions.

What Are the Side Effects of Lemborexant (Dayvigo)?

Drowsiness and Daytime Functional Impairment

The most common side effect is drowsiness (incidence ≥ 5%), which is more pronounced especially at higher doses (10mg).

Other central nervous system (CNS) depressant symptoms include dizziness and fatigue, and the risk of falls increases in the elderly.

Sleep-Related Abnormal Behaviors

Complex sleep behaviors: Such as sleepwalking, sleep-eating, or sleep-driving. These behaviors may not be remembered, and the medication must be discontinued immediately followed by medical consultation.

Sleep paralysis and hallucinations: Manifested as temporary inability to move or vivid hallucinations, mostly occurring during sleep transitions.

Effects on Mood and Respiration

It may exacerbate depression or suicidal tendencies, and close monitoring is particularly necessary for patients with a history of mental illness.

Caution is required for patients with moderate to severe obstructive sleep apnea (OSA) or chronic lung disease, as it may worsen respiratory depression.

Methods to Alleviate the Side Effects of Lemborexant (Dayvigo)

Dosage and Medication Timing Adjustment

The initial dose is 5mg, and the dose should be adjusted gradually based on tolerability, with a maximum daily dose not exceeding 10mg.

Take the medication immediately before bedtime and ensure at least 7 hours of sleep after administration to reduce daytime drowsiness.

Avoiding Triggers

Diet: High-fat meals may delay the drug's effect, so it is recommended to take the medication on an empty stomach or after a light meal.

Alcohol and CNS depressants: Concomitant use (e.g., with benzodiazepines, opioids) is prohibited to prevent exacerbation of sedative effects.

Monitoring and Management

Record abnormal sleep behaviors or mood changes, and seek medical attention promptly.

Regular assessments are required for elderly patients or those with liver impairment; the dose for patients with moderate liver impairment should not exceed 5mg.

Daily Precautions for Lemborexant (Dayvigo)

Medication Safety

Avoid sudden discontinuation of the medication; regular follow-up visits are needed to evaluate efficacy and safety during long-term use.

Store the medication out of the reach of children to prevent accidental ingestion.

Activity and Lifestyle Management

Avoid getting up and moving around at night after taking the medication to reduce the risk of falls.

Ensure full alertness the next day before driving or operating machinery; if necessary, suspend high-risk activities.