Artesunate is an antimalarial drug independently developed by China. Since it was launched in China in 1987, it has become an important drug in the global fight against malaria. It is listed as one of the essential antimalarial drugs by the World Health Organization and was approved for marketing by the US FDA in 2020.

What diseases does artesunate treat?

Artesunate is a drug specifically used to treat malaria, especially for patients with severe malaria. Malaria is an infectious disease caused by Plasmodium, which can be life-threatening in severe cases. The emergence of artesunate has provided important support for global antimalarial treatment.

Indications and target populations

Artesunate is suitable for the initial treatment of severe malaria in adults and children. Severe malaria is usually accompanied by high fever, coma or multiple organ dysfunction, requiring rapid intervention. Artesunate takes effect quickly through intravenous injection, buying time for subsequent oral antimalarial treatment.

Target and pharmacological mechanism

Artesunate targets ATP2A1 and SERCA2, and causes death by interfering with the calcium ion balance of malarial parasites. This unique mechanism makes it highly selective for malarial parasites and reduces damage to host cells.

The application of artesunate in the field of antimalarial has not only saved countless lives, but also provided a powerful tool for global malaria prevention and control. Its precise mechanism of action and wide adaptability make it the first choice for antimalarial treatment.

How is the therapeutic effect of artesunate?

Artesunate occupies an important position in antimalarial treatment with its rapid onset and high efficiency. Its clinical effect has been verified by many international studies and has become the core drug for the treatment of severe malaria.

Clinical efficacy and advantages

Artesunate shows obvious clinical efficacy in the treatment of severe malaria. Studies have shown that it can quickly reduce the number of malarial parasites in patients and relieve symptoms. Compared with other antimalarial drugs, artesunate has a shorter onset time and is particularly suitable for the rescue of critically ill patients.

Adverse reactions and risk management

Although artesunate has obvious efficacy, its potential adverse reactions still need to be paid attention to. Common adverse reactions include acute renal failure, hemoglobinuria and jaundice. In addition, delayed hemolysis and allergic reactions also need to be closely monitored. Doctors need to weigh the pros and cons according to the patient's condition and clarify the safety of medication.

The high efficiency of artesunate makes it an important choice for antimalarial treatment, but reasonable use and risk management should not be ignored. Through scientific medication and close monitoring, its therapeutic effect can be maximized.

Basic drug information of artesunate

Artesunate is an important antimalarial drug. Its basic drug information covers dosage form, usage, storage and other aspects. Understanding this information will help to better apply and manage this drug.

Dosage form and usage and dosage

The main dosage form of artesunate is injection, with a specification of 110mg/bottle. It needs to be dissolved with the accompanying buffer when used, and it is a colorless and transparent solution after preparation. The recommended dose is 2.4mg/kg, and multiple doses are required in the initial stage, and then converted to once a day.

Storage and shelf life

Unprepared artesunate must be stored at 20°C--25°C away from light, and the shelf life is up to 36 months. The prepared solution must be used within 1.5 hours and must not be frozen. Reasonable storage conditions are important for confirming the effect of the drug.

The basic drug information of artesunate provides clear guidance for clinical use. From dosage form to storage, every detail is related to the safety and effectiveness of the drug, and relevant regulations must be strictly followed.

[Special reminder] Please consult a doctor for specific indications and do not take the drug privately.