This article introduces the use of Reblozyl in specific populations to help patients avoid risks.
Use of Reblozyl in specific populations
Pregnancy
According to the results of animal studies, pregnant women using Reblozyl may cause harm to the fetus.
Lactation
Animal studies have shown that breast-fed children may experience serious adverse reactions, so it is recommended that lactating patients not breastfeed during treatment with Reblozyl and within 3 months after the last dose.
Women and men with fertility plans
It is recommended that women with fertility plans take a pregnancy test before receiving Reblozyl treatment.
Pregnant women may suffer embryo-fetal damage during treatment with Reblozyl, and female patients with fertility plans are advised to take effective contraceptive measures during treatment and for at least 3 months after the last dose.
According to the results of animal studies, Reblozyl may impair the fertility of female animals. The adverse effects on the fertility of female organisms are reversible after a 14-week recovery period.
Use in pediatric patients
The safety and efficacy of Reblozyl in pediatric patients have not been established. Based on animal studies, Reblozyl is not recommended for use in pediatric patients.
Use in Elderly Patients
Clinical trials for use in elderly patients with beta-thalassemia did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently from younger patients.
In clinical studies of Reblozyl for the treatment of MDS-RS and MDS/MPN-RS-T anemia, 206 (79%) patients were ≥ 65 years of age and 93 (36%) patients were ≥ 75 years of age. There were no differences in safety or effectiveness between elderly and younger patients.
Precautions
Before receiving Reblozyl, tell your doctor if you have or have had blood clots; Have or have had high blood pressure (hypertension); Take hormone replacement therapy or birth control pills (oral contraceptives); Have had your spleen removed (splenectomy); Do you smoke;Are you pregnant or planning to become pregnant.
