Canakinumab is a prescription drug that has been marketed in the United States and China. It is an important therapeutic drug used to treat a variety of diseases. However, the use of canakinumab requires following some important precautions to ensure safe and effective treatment. This article will detail the precautions and drug interactions of canakinumab during use.

Precautions for Canakinumab

This article will introduce the precautions that should be noted when using canakinumab. These include dosage, method of use, storage, and expiration date, etc.

Correct Dosage Administration

When using canakinumab, the correct dosage should be administered in accordance with the doctor's advice and prescription. The dosage depends on the patient's specific situation and the disease to be treated. Do not adjust the dosage on your own to avoid affecting the treatment effect or causing unnecessary side effects.

Correct Method of Use

Canakinumab is usually administered to patients by injection. Before use, you should carefully read the drug instruction manual to understand the correct method of use. If you are unsure about how to use it correctly, please consult a doctor or medical professional for guidance. During injection, correct disinfection measures should be taken, and the operation should be carried out in strict accordance with the requirements for injection sites and injection speed.

Storage Requirements

Unopened vials of canakinumab must be stored in the original packaging, refrigerated at 2-8°C and protected from light. Do not freeze canakinumab, as freezing will affect the stability and activity of the drug. At the same time, canakinumab should be kept away from children and pets, and should not be exposed to high temperature, humidity or direct sunlight.

Attention to Expiration Date

Before using canakinumab, be sure to check the expiration date of the drug. Expired drugs may have lost their effectiveness and may even cause adverse effects on the body. If the drug has expired, it should be disposed of properly and not used.

The use of canakinumab is an important treatment, but it requires following some important precautions. Correct dosage administration, method of use, storage, and attention to expiration date are the keys to ensuring safe and effective treatment. Before using canakinumab, be sure to consult a doctor and use it in accordance with the doctor's guidance. If you have any questions or discomfort, you should report to the doctor in a timely manner.

Drug Interactions of Canakinumab

Although no formal studies have been conducted to explore the interactions between canakinumab and other drugs, some known interactions require patients to be cautious when using it in combination with other drugs.

Interactions with TNF Blockers and IL-1 Blockers

Canakinumab is an antibody drug that can block the action of tumor necrosis factor (TNF). When used in combination with other TNF blockers and IL-1 blockers, it may increase the risk of adverse reactions. Therefore, when using these drugs in combination, both patients and doctors need to closely monitor the patient's condition and adverse reactions, and adjust the dosage or discontinue use as needed.

Interactions with Immunizations

Canakinumab can affect the function of the immune system, so during treatment with canakinumab, patients may have a reduced ability to respond immunologically to vaccines. When considering vaccination, patients should discuss with their doctor and decide whether to postpone or adjust the vaccination time based on specific circumstances.

Interactions with Cytochrome P450 Substrates

Canakinumab may interfere with the activity of cytochrome P450 enzymes during its metabolism in the body, which may affect the metabolism and elimination of other drugs. When using canakinumab in combination with other drugs, especially those mainly metabolized by cytochrome P450 enzymes in the body, both patients and doctors should closely monitor the patient's drug concentration and adverse reactions.

Although the interactions between canakinumab and other drugs have not been fully studied, based on known interaction mechanisms, patients should be cautious when using canakinumab in combination with other drugs. It is recommended that patients consult a doctor before combined medication to understand the possible risks of interactions and formulate a reasonable treatment plan based on specific circumstances. At the same time, doctors should also closely monitor the patient's condition and adverse reactions to ensure the effectiveness and safety of treatment.