Fostamatinib is a drug used to treat blood diseases. It is available in tablet formulations of 100mg and 150mg, and its price varies depending on regions and supply channels. Patients need to obtain a prescription from a professional medical institution and use the drug under the guidance of a doctor.

Indications of Fostamatinib (Tavalisse)

Indications

Fostamatinib is the world's first and only approved oral spleen tyrosine kinase (SYK) inhibitor. It is used to treat thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP), especially those who have had an inadequate response to previous treatments.

Recommended Dosage

Initial dose

100 mg orally, twice daily. Patients may choose to take it with or without meals.

Dose adjustment

After one month of taking fostamatinib, the doctor will re-evaluate the patient's platelet count. If the platelet count does not increase to at least 50 x 10^9/L, the doctor may decide to increase the dose to 150 mg twice daily.

Principles of dose adjustment

Based on individual safety and tolerability, doctors may recommend adjusting the dose of fostamatinib. If adverse reactions occur, it may be necessary to interrupt, reduce, or discontinue the dose. If the patient is at the maximum dose (150 mg twice daily) when adverse reactions occur, the dose will be reduced from 300 mg/day to 200 mg/day, i.e., 100 mg twice daily.

Patients should undergo regular blood tests while taking fostamatinib to monitor platelet counts and therapeutic efficacy. If a dose is missed, it should be taken as soon as the patient remembers. If multiple doses are accidentally missed, the doctor should be consulted promptly.

Precautions for Taking Fostamatinib

Fostamatinib (Tavalisse) is a drug used to treat chronic immune thrombocytopenia (ITP). The following are some precautions to note when using fostamatinib:

Monitoring of adverse reactions

Fostamatinib may cause some side effects, including headache, fatigue, diarrhea, nausea, etc. If severe adverse reactions occur, such as severe allergic reactions, difficulty breathing, bleeding, etc., the doctor should be informed immediately, and treatment should be carried out according to the doctor's guidance.

Drug interactions

Fostamatinib may interact with other drugs, especially those that may increase the risk of bleeding, such as anticoagulants, non-steroidal anti-inflammatory drugs, etc. Before starting to use fostamatinib, patients should inform the doctor of other drugs they are taking, including prescription drugs, over-the-counter drugs, and supplements.

Fostamatinib is not suitable for specific populations such as pregnant women, minors, and the elderly. Patients with liver disease, kidney disease, or heart disease should use it with caution and closely monitor relevant indicators. Patients should strictly follow the doctor's advice, paying attention to the usage and dosage, monitoring of adverse reactions, drug interactions, and contraindications for use in special populations.