Ogsiveo (OGSIVEO, nirogacestat) is a systemic treatment drug for progressive desmoid tumors. Since it was successfully launched in the United States on May 19, 2023, it has received widespread attention. Then, what are the precautions for Ogsiveo?

Precautions for Ogsiveo

When purchasing and using this drug, patients should fully understand the precautions for medication in special populations and other information.

Women and men of reproductive potential

The impact of Ogsiveo on fertility has not been fully clarified, but according to the results of animal studies, the drug may impair the fertility of both women and men.

Pediatric and elderly patients

The safety and effectiveness of Ogsiveo in pediatric patients have not been determined, and the risks and benefits should be carefully evaluated when using it in pediatric patients. When using Ogsiveo, individual evaluation should be conducted according to the specific conditions of elderly patients.

Genuine purchasing channels for Ogsiveo

Ogsiveo is developed by SpringWorks Therapeutics, Inc. in the United States.

Official channels and professional medical institutions

For patients in need, the most reliable way is to consult and purchase through official channels or professional medical institutions. Patients can contact SpringWorks Therapeutics, Inc. to learn about the latest listing information and purchasing procedures of the drug.

Overseas drug purchase and compliance

For some patients in urgent need of medication, they may consider obtaining Ogsiveo through overseas drug purchase. When choosing to purchase drugs overseas, patients must act cautiously and understand and abide by the relevant import regulations and procedures.

Drug interactions of Ogsiveo

Ogsiveo is mainly metabolized in the liver, and its metabolic pathways include oxidation and reduction mediated by CYP3A4. When used in combination with other drugs that go through the same metabolic pathway, drug interactions may occur, affecting the efficacy and safety of the drug.

Mechanism of drug interactions

At present, the specific information on the interactions between Ogsiveo and other drugs is not clear. Before taking the drug, patients should inform the doctor in detail of all the drugs they are taking, including prescription drugs, over-the-counter drugs, herbal medicines and supplements, so that the doctor can assess the potential risk of drug interactions.

Potential risks of drug interactions

Combined use with CYP3A4 inhibitors may increase the blood concentration of Ogsiveo, thereby increasing the risk of adverse reactions; while combined use with CYP3A4 inducers may reduce the blood concentration of Ogsiveo and affect its efficacy. Patients should pay close attention to their physical conditions during medication and seek medical attention in time if they feel unwell.

Doctors should also formulate personalized medication plans according to the specific conditions of patients, closely monitor the patients' drug responses and adverse reactions, and provide scientific and comprehensive medication guidance for patients.