Defibrotide is an oligonucleotide drug derived from natural DNA degradation products, with antithrombotic and fibrinolytic properties. It is mainly used for the treatment of hepatic veno-occlusive disease after hematopoietic stem cell transplantation.

Where to buy defibrotide at a lower price?

The purchase price of defibrotide varies due to multiple factors, including production costs, market demand, brand effect, and regional differences. To determine where to buy it cheaper, the following aspects need to be considered:

Purchase through regular channels

Patients should choose regular channels to buy defibrotide, such as officially authorized sales platforms or regular overseas channels. These channels can usually provide genuine product guarantees and ensure the quality of the medicine.

Price comparison

Defibrotide has not yet been approved for marketing in China, so domestic patients cannot buy it directly. In the international market, the price of defibrotide may vary due to factors such as region and brand. Patients can learn about the prices in the international market through regular overseas channels for comparison.

When buying defibrotide, patients should obtain a doctor's prescription and use the medicine correctly as directed by the doctor. Never buy defibrotide from unknown sources to avoid purchasing counterfeit and shoddy products.

Dosage and administration of defibrotide

The dosage and administration of defibrotide need to be determined according to the specific situation of the patient and the doctor's advice.

Administration method

Route of administration: Defibrotide is usually given to patients in the form of an injection, and intravenous infusion is used to achieve the best curative effect. Injections need to be used under the supervision of clinical facilities or medical professionals.

Infusion time: The intravenous infusion time of defibrotide is usually 2 hours, administered once every 6 hours.

Dosage

Recommended dosage: The recommended dosage of defibrotide is 6.25mg/kg body weight, and this dosage should be based on the patient's baseline weight, that is, the patient's weight before the HSCT conditioning regimen.

Individual differences among patients may affect the dosage of defibrotide. Patients should strictly follow the doctor's guidance, maintain close communication with the doctor during treatment, and pay attention to the contraindications of the drug.

Contraindications of defibrotide

The contraindications of defibrotide mainly include the following two aspects:

Prohibited concurrent use with systemic anticoagulant or fibrinolytic therapy

Defibrotide has the effect of enhancing plasmin activity, and it may increase the risk of bleeding in patients. Concurrent use with systemic anticoagulants or fibrinolytic therapy will further aggravate the risk of bleeding.

Known allergy to defibrotide or any of its excipients

If a patient has an allergic reaction to defibrotide or any of its excipients, severe hypersensitivity reactions may occur. Patients who are allergic to the drug are strictly prohibited from using it.

In clinical application, both doctors and patients should strictly abide by the relevant contraindications and precautions to reduce drug side effects and avoid unnecessary risks.

Warm reminder: Defibrotide has the effects of promoting fibrinolysis and antithrombosis, and may also increase the risk of bleeding. During use, patients should closely monitor their own bleeding situation. If abnormal bleeding symptoms occur, they should seek medical attention in time.