Zolbetuximab is a synthetic IgG1 monoclonal antibody drug targeting Claudin 18.2 (CLDN18.2). It has demonstrated significant efficacy in the treatment of unresectable advanced recurrent gastric cancer positive for CLDN18.2. The original Zolbetuximab product, manufactured by Astellas Pharma of Japan with a specification of 100mg per vial, is priced at approximately 1,182 US dollars per box.

How Much Does Zolbetuximab Cost?

Zolbetuximab is produced by Astellas Pharma (Japan). The original drug, with a specification of 100mg/vial, costs approximately 1,482 US dollars per box. This price is for reference only; the actual purchase price may vary depending on factors such as region, distribution channel, and purchase quantity.

Factors Affecting the Price

The price of Zolbetuximab is influenced by multiple factors. Original drugs are generally more expensive, as their high research and development costs, production costs, and patent protection all contribute to the elevated pricing. Additionally, the economic development level, medical policies, and market competition in different regions also exert an impact on the price.

Price Trend

With the continuous advancement of medical technology and the intensification of market competition, the price of Zolbetuximab is expected to gradually decrease. The launch of generic versions will increase market supply, thereby lowering the price of the original drug. The implementation of policies such as government-led price negotiations and medical insurance reimbursement will also help reduce the medication costs for patients. The specific price trend still needs to be determined based on market changes and policy adjustments.

Market Launch and Medical Insurance Coverage of Zolbetuximab

Zolbetuximab has been approved for marketing in Japan, making it the first and currently the only CLDN18.2-targeted therapy approved by a global regulatory authority. In China, Zolbetuximab has also been officially launched.

Market Launch Process

The market launch of Zolbetuximab went through multiple phases. It was approved for marketing in Japan on March 26, 2024, and its research and development process was filled with challenges and breakthroughs.

Medical Insurance Reimbursement Status

Currently, Zolbetuximab has not been included in China's National Reimbursement Drug List (NRDL). This means that patients need to bear the full cost of purchasing the drug, resulting in a heavy economic burden. With the continuous improvement of national medical insurance policies and the establishment of anti-cancer drug negotiation mechanisms, Zolbetuximab is expected to be included in the scope of medical insurance reimbursement in the future, thereby alleviating the economic burden on patients.

Procurement Channels for Zolbetuximab

For patients in need of purchasing Zolbetuximab, there are currently multiple channels available.

Overseas Drug Procurement

For patients who cannot purchase Zolbetuximab through formal domestic channels, overseas drug procurement is a feasible option. However, this requires patients to have access to appropriate procurement channels and the financial capacity to afford it, as well as a good understanding of the laws, regulations, and import policies of the relevant countries.

Clinical Trials

Participating in clinical trials allows patients to use Zolbetuximab for free under the guidance of professional doctors, and they may also have the opportunity to achieve better treatment outcomes. It should be noted that both of these methods carry certain risks and uncertainties. Patients need to make decisions after fully understanding the relevant information and weighing the pros and cons.

Patients and their family members need to fully understand the relevant information and make informed decisions to ensure that patients can receive timely and effective treatment.