Dacomitinib is a targeted drug for non-small cell lung cancer (NSCLC) with positive EGFR mutations. Its medical insurance reimbursement status, medication precautions, and dietary coordination are of great importance to the treatment effect. This article will elaborate on these three aspects to help patients use this drug in a standardized manner.

Medication Precautions for Dacomitinib

Correct use of Dacomitinib is crucial for ensuring therapeutic efficacy and reducing adverse reactions. The following are the precautions that require special attention.

Management of Adverse Reactions

Common adverse reactions include diarrhea, rash, etc. In case of grade 2 or higher diarrhea, medication should be suspended and anti-diarrheal treatment initiated immediately. For persistent grade 2 rash or grade 3 or higher rash, temporary drug withdrawal is necessary, and topical or oral antibiotics should be used. The incidence of interstitial lung disease is low but potentially fatal; if dyspnea occurs, seek medical attention immediately.

Drug Interactions

Avoid concurrent use with proton pump inhibitors (such as omeprazole), as this will reduce the blood concentration of Dacomitinib. If antacid treatment is required, it is recommended to use local antacids or H2 receptor antagonists (such as ranitidine), and the administration should be spaced by 6-10 hours. Understanding these precautions and conducting regular follow-up examinations can maximize the therapeutic effect and ensure medication safety.

Dietary Precautions for Dacomitinib

Reasonable dietary coordination can improve the therapeutic effect of Dacomitinib and reduce adverse reactions. The following are specific dietary recommendations.

Medication Time and Diet

Dacomitinib can be taken with food or on an empty stomach, but the daily medication method must be consistent. It is recommended to take the drug at the same fixed time every day, such as after breakfast or before dinner, to improve the stability of blood drug concentration.

Diet During Diarrhea

During diarrhea, high-fiber and high-fat foods should be avoided; instead, low-residue foods such as white porridge and noodles are recommended. Eat small meals frequently and supplement electrolyte water to prevent dehydration. Appropriate consumption of pectin-rich foods such as applesauce and bananas is allowed.

Nutritional Support Recommendations

Decreased appetite and weight loss are common during treatment, so sufficient intake of calories and protein is essential. Choose foods with high nutritional density, such as eggs, fish, and dairy products. If necessary, use nutritional supplements under the guidance of a doctor.

Scientific and reasonable dietary coordination can help alleviate drug adverse reactions, maintain a good nutritional status, and enhance the therapeutic effect.