Riociguat Tablets (Adempas) is a soluble guanylate cyclase stimulant, mainly used for the treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.

How to Purchase Riociguat Tablets (Adempas)

Overseas Purchasing

Patients may choose to consult and purchase Riociguat Tablets at hospital pharmacies or legitimate drugstores in countries or regions where the drug has been launched.

Since drug prices may be affected by factors such as regional differences and exchange rate fluctuations, patients need to make budgets and plans in advance before purchasing.

Purchasing through Medical Service Institutions

Patients can consult domestic overseas medical service institutions that cooperate with international pharmacies or pharmaceutical companies.

These institutions usually provide legal import channels and offer professional consultation and guidance.

Precautions for Purchase and Use of Riociguat Tablets (Adempas)

Absolutely Contraindicated Populations

Pregnant women.

Patients using nitrates or nitric oxide donors simultaneously.

Patients using phosphodiesterase inhibitors.

Patients using other soluble guanylate cyclase stimulants concurrently.

Patients with pulmonary arterial hypertension associated with idiopathic interstitial pneumonia.

Special Risk Warnings

Embryotoxicity Risk: The drug has a teratogenic risk to the fetus. Pregnancy must be ruled out before medication use, and effective contraceptive measures must be continuously adopted during treatment.

Hypotension Risk: The drug can lower blood pressure. Special caution is required for patients with hypovolemia, severe left ventricular outflow tract obstruction, etc.

Bleeding Risk: Clinical trials show that the incidence of severe bleeding in patients taking Riociguat Tablets is 2.4%.

Medication for Special Populations

Renal Impairment: Not recommended for patients with a creatinine clearance rate < 15 mL/min or those receiving dialysis.

Hepatic Impairment: Not recommended for patients with severe hepatic impairment.

Smoking Patients: Dose adjustment may be required. The plasma concentration in smokers is 50%-60% lower than that in non-smokers.

How to Identify the Authenticity of Riociguat Tablets (Adempas)

Identification of Appearance Characteristics

0.5mg: White film-coated tablets, engraved with the "BAYER" cross logo on one side, and "0.5" and "R" on the other side.

1mg: Pale yellow film-coated tablets, engraved with the "BAYER" cross logo on one side, and "1" and "R" on the other side.

1.5mg: Yellow-orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "1.5" and "R" on the other side.

2mg: Pale orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "2" and "R" on the other side.

2.5mg: Red-orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "2.5" and "R" on the other side.

Inspection of Packaging Markings

Clear production batch number and expiration date.

Complete drug instruction manual.

Anti-counterfeiting marks and REMS (Risk Evaluation and Mitigation Strategy) program certification information.

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