Factors Affecting the Price of Urief

When antihypertensive drugs are used in combination, the risk of orthostatic hypotension may increase. This is caused by a decrease in blood pressure regulatory capacity. During use, attention should be paid to monitoring blood pressure, and the dosage of antihypertensive drugs should be adjusted according to the situation.

Concomitant use of PDE5 inhibitors such as sildenafil with silodosin may cause symptomatic hypotension. This is due to the enhanced vasodilatory effect. Concurrent use should be avoided, or if necessary, it should be used cautiously under the guidance of a doctor.

Azole antifungal drugs such as itraconazole may increase the plasma concentration of silodosin. This is because they inhibit the activity of CYP3A4 enzyme, which slows down the metabolism of silodosin. When using them together, consideration should be given to adjusting the dosage of silodosin.