MEXTOVI(Binimetinib) Side Effects

Common adverse reactions include fatigue, nausea, and diarrhea; serious risks include cardiomyopathy and hemorrhage.

Adverse Reactions

The most frequently reported adverse reactions (≥25%) when combined with encorafenib include fatigue, nausea, diarrhea, vomiting, and abdominal pain in melanoma patients, with NSCLC patients additionally experiencing musculoskeletal pain, visual impairment, constipation, dyspnea, rash, and cough. Serious adverse reactions can include new primary malignancies (cutaneous and non-cutaneous), cardiomyopathy, venous thromboembolism, ocular toxicities such as serous retinopathy and retinal vein occlusion, hepatotoxicity, rhabdomyolysis, and hemorrhage.