How should I use this medicine?

The recommended dosage of KINERET varies based on the condition being treated, with specific adjustments for renal impairment.

Dosage Regimens for KINERET (Anakinra)

For rheumatoid arthritis (RA), KINERET is administered at a dose of 100 mg/day by subcutaneous injection. For patients with severe renal insufficiency or end-stage renal disease (creatinine clearance <30 mL/min), a reduced dosage of 100 mg every other day is recommended. For NOMID and DIRA, the initial dose is 1-2 mg/kg/day, adjustable up to 8 mg/kg/day, depending on patient response. In cases of renal impairment, a similar adjustment to every other day dosing is advised. Dosage must be individualized, considering the patient’s renal function and condition.