How should I use Zydelig(Idelalisib)?

The recommended starting dose of Zydelig is 150 mg orally twice daily, with adjustments based on toxicity.

Standardized Dosing and Adjustment Protocols for Zydelig

The initial recommended dose of Zydelig (idelalisib) is 150 mg administered orally twice daily, regardless of food intake. Tablets should be swallowed whole. Treatment is continued until disease progression or unacceptable toxicity occurs. 

 Dose modifications are mandated for specific adverse events: for example, if severe or life-threatening toxicities arise, Zydelig should be withheld until resolution, then resumed at a reduced dose of 100 mg twice daily. Permanent discontinuation is required for recurrent or certain severe toxicities. The optimal duration of therapy beyond several months is not specified in the description.