How should I use VANFLYTA(Quizartinib)?

VANFLYTA dosage is tailored to the specific phase of AML treatment—induction, consolidation, or maintenance—and requires careful adherence to administration guidelines.

VANFLYTA Dosing Regimen and Administration

The recommended dosage of VANFLYTA varies by treatment phase. During induction with 7+3 chemotherapy, 35.4 mg is administered orally once daily starting on Day 8 for two weeks per cycle (Days 8-21). For consolidation with high-dose cytarabine, 35.4 mg is given orally once daily starting on Day 6 for two weeks per cycle (Days 6-19). Maintenance therapy begins with 26.5 mg orally once daily for Days 1-14 of the first cycle, increasing to 53 mg once daily from Day 15 if QTcF ≤≤ 450 ms, continued for up to 36 cycles. Tablets should be swallowed whole, with or without food, at approximately the same time each day. If a dose is missed or vomited, it should not be replaced; the next dose should be taken as scheduled.