Aceclidine Eye Drops (Aceclidine) is a novel cholinergic agonist first approved in the United States in 2025, offering an innovative treatment option for patients with presbyopia. Proper administration of the drug and establishment of a comprehensive monitoring system are crucial for ensuring therapeutic efficacy and patient safety.
What are the Precautions for Using Aceclidine Eye Drops (Aceclidine)?
Patient Screening and Contraindication Assessment
Aceclidine Eye Drops are indicated for adult patients with presbyopia, but a comprehensive evaluation must be conducted prior to medication use.
This drug is contraindicated in patients with known hypersensitivity to aceclidine or any of its components.
It is important to note that the package insert clearly states there are currently no absolute contraindications, but this does not mean that the assessment of individual differences can be neglected.
Baseline Retinal Examination
Due to warnings regarding the risk of retinal tear/detachment, it is recommended that all patients undergo a retinal examination before initiating treatment.
This step is particularly important for identifying populations at high risk of retinal lesions, which can effectively prevent the occurrence of serious complications.
Special Population Assessment
Extra caution is required for patients with a history of uveitis, as miotics may exacerbate inflammatory sequelae such as synechiae between the iris and lens.
Such patients should use the drug under strict medical supervision, with close monitoring of inflammatory responses.
Contact Lens Usage Guidelines
Patients wearing contact lenses must remove the lenses before instilling the drops and wait at least 10 minutes after instillation before reinserting the lenses.
This interval is established based on considerations of potential interactions between the drug and contact lens materials.
Scheduling of Combined Medication Use
When multiple ophthalmic medications need to be used simultaneously, an interval of at least 5 minutes should be maintained between different products.
This ordered administration schedule prevents mutual flushing of drugs and ensures adequate absorption of each medication.
Early Warning of Retinal Complications
Although retinal tear/detachment is rare, patients must be aware of relevant warning signs.
Sudden onset of photopsia, floaters, or vision loss requires immediate medical attention, as these may be early symptoms of retinal problems.
Monitoring for Allergic Reactions
Close observation for allergic reactions is necessary during the first use.
Since the eye drops contain various excipients, including polysorbate 80, mannitol, and hypromellose, any abnormal reactions should be reported promptly.
Medication Monitoring for Aceclidine Eye Drops (Aceclidine)
Efficacy Monitoring Standards
Treatment efficacy is evaluated based on strict criteria: an improvement of 3 lines or more in high-contrast, distance-corrected near visual acuity at 40 cm, while distance-corrected far visual acuity at 4 meters does not decrease by more than 1 line.
Key Focuses for Adverse Reaction Monitoring
Based on clinical trial data, the following adverse reactions require key monitoring: instillation site irritation (20%), blurred vision (16%), headache (13%), conjunctival hyperemia (8%), and ocular hyperemia (7%).
Most reactions are mild, transient, and resolve spontaneously.
