As an important pharmaceutical ingredient, Metyrapone has a wide range of applications in the medical field. This article will elaborate on the indications, recommended dosage, and precautions for the use of Metyrapone, in order to provide readers with comprehensive and accurate information.

What diseases is Metyrapone suitable for?

Metyrapone plays an important role in the diagnosis of specific diseases as a diagnostic aid.

Diagnosis of adrenal insufficiency

Metyrapone is used in combination with other diagnostic tests for the diagnosis of adrenal insufficiency in adults and children. By measuring the levels of specific hormones in the plasma after taking the drug, doctors can assess the patient's adrenal function status.

Adaptation to target CYP11B1

Metyrapone acts on CYP11B1 target, which is a key enzyme in the adrenocorticotropic hormone synthesis pathway. By inhibiting the activity of this enzyme, Metyrapone can alter the concentration of related hormones in the blood plasma, thereby aiding diagnosis.

Although Metyrapone has performed well in the diagnosis of adrenal insufficiency, it is not currently widely used in the treatment of other diseases. Its indications are relatively limited, but its value in the field of diagnosis cannot be ignored.

What is the recommended dosage of Metyrapone?

Knowing the recommended dosage of Metyrapone is essential to ensure the accuracy of the diagnosis.

Recommended dose for a single-dose short-acting trial

In adult and pediatric patients, a single dose of 30 mg/kg (up to 3 g) is recommended. This dose is usually given at midnight with milk/yogurt or snacks so that a blood sample can be taken early the next morning for assay.

Dose adjustment and monitoring

Dose adjustments should be made according to the patient's specific situation and the doctor's guidance. After dosing, the patient's plasma hormone levels should be closely monitored to ensure diagnostic accuracy.

Metyrapone is not marketed in China and has not entered the Chinese medical insurance. Patients will need to purchase this medicine through other means.

What are the precautions for the use of Metyrapone?

When using Metyrapone, patients should strictly follow their doctor's instructions and pay attention to the following.

Risk in patients with adrenal insufficiency

Metyrapone can cause acute adrenal insufficiency in patients with decreased adrenal secretion and in patients with pituitary insufficiency. In cases where adrenal insufficiency is suspected, the test should be performed under close hospital monitoring.

Avoid concomitant use with other medications

Anticonvulsants, psychotropic medications, hormonal preparations, corticosteroids, antithyroid drugs, and cyproheptadine can all affect the results of a metopirax test. If these drugs cannot be discontinued, the need for a Metyrapone trial should be reviewed.

Storage and custody requirements

Metyrapone should be shaded, sealed, stored in a dry place, and controlled at 20°C-25°C. Avoid exposing the drug to extreme heat or cold temperatures to ensure the stability and efficacy of the drug.

As an important diagnostic adjunct, Metyrapone plays a key role in the diagnosis of adrenal insufficiency. Understanding the indications, recommended dosage and precautions for use of Metyrapone is essential to ensure diagnostic accuracy and patient safety. When using Metyrapone, patients should strictly follow their doctor's instructions and pay attention to the storage and custody requirements of the drug.