Common adverse reactions of Ivosidenib(Tibsovo) include fatigue, arthralgia, diarrhea, edema, nausea, dyspnea, mucositis, rash, etc. There may also be some more serious adverse reactions, such as differentiation syndrome, QTc interval prolongation, Guillain-Barré syndrome, etc. Patients should pay close attention to their physical condition while taking the drug, and if they experience any discomfort, they should seek medical attention immediately and inform their doctor that they are taking Ivosidenib(Tibsovo).

What are the adverse effects of Ivosidenib(Tibsovo)?

Understanding the adverse effects of Ivosidenib(Tibsovo) helps patients and doctors to identify and deal with them in a timely manner during use.

Common adverse reactions

During the treatment of Ivosidenib(Tibsovo), patients may experience common adverse reactions such as fatigue, arthralgia, diarrhea, edema, nausea, dyspnea, mucositis, rash, etc., which are observed in ≥20% of patients.

Serious adverse reactions

Some patients may have serious adverse reactions such as differentiation syndrome, QTc interval prolongation, and Guillain-Barré syndrome. Differentiation syndrome is associated with rapid proliferation and differentiation of bone marrow cells and can be life-threatening; Prolonged QTc interval may increase the risk of ventricular arrhythmias; Guillain-Barré syndrome can lead to motor and/or sensory neuropathy.

Response

Patients should inform their doctor of adverse reactions in a timely manner. Depending on the severity of the symptoms, the doctor will take appropriate measures, such as stopping the drug, reducing the dose, or giving symptomatic treatment.

Understanding the adverse effects of Ivosidenib(Tibsovo) helps patients and physicians to monitor and manage risks during treatment.

Ivosidenib(Tibsovo) overdose

Drug overdose can lead to worsening of adverse effects, and it is important to understand the overdose management measures for Ivosidenib(Tibsovo).

Symptoms of drug overdose

An overdose of the drug Ivosidenib(Tibsovo) may cause abnormal blood concentrations to rise, which can exacerbate the symptoms of common and serious adverse reactions, such as severe nausea, vomiting, diarrhea, dyspnea, etc.

Measures

Once an overdose occurs, administration should be stopped immediately and the patient should be closely monitored for changes in vital signs and symptoms. If necessary, symptomatic treatment, such as gastric lavage, catharsis, and rehydration, may be given to accelerate drug excretion and reduce symptoms.

Precautionary measures

To prevent drug overdose, patients should strictly follow their doctor's instructions and avoid increasing the dose or changing the frequency of medication. Family members and caregivers should pay close attention to the patient's medication to ensure that the medication is safe.

Understanding Tibsovo's overdose measures can help you respond effectively and promptly in unexpected situations to ensure patient safety.

How to use the drug for special groups of people with Ivosidenib(Tibsovo)?

Special attention should be paid to the medication of special populations to ensure the safety of medication.

Pregnant and lactating women

Women should avoid Ivosidenib(Tibsovo) during pregnancy because of the potential for harm to the fetus. Breastfeeding women should stop breastfeeding while taking the drug to avoid passing the drug to the baby through breast milk.

Elderly patients

Elderly patients do not need to adjust the dose of Ivosidenib(Tibsovo), but their liver and kidney function should be closely monitored to ensure the safety of the medication.

Patients with hepatic and renal insufficiency

For patients with mild or moderate hepatic or renal impairment, the starting dose of Ivosidenib(Tibsovo) does not need to be adjusted. It should be used with caution in patients with severe hepatic and renal impairment, and the risks and potential benefits should be assessed under the guidance of a physician.

As a treatment for AML targeting IDH1 mutations, it is necessary to pay close attention to the adverse reactions, drug overdose treatment and drug use in special populations during the use of Ivosidenib(Tibsovo). By understanding this critical information, patients and physicians can work together to develop safer, more effective treatment options that improve treatment outcomes and reduce risk.