Selpercatinib(Retevmo) is a targeted drug that has demonstrated significant efficacy in the treatment of non-small cell lung disease and thyroid disease.

Are the adverse effects of Selpercatinib(Retevmo) serious?

Selpercatinib may also trigger a range of adverse effects when used, the severity of which varies from individual to individual, but patients and physicians alike should remain vigilant.

High blood pressure

Up to 35% of patients develop hypertension after taking Selpercatinib, and some of them have blood pressure levels of grade 3 or 4. High blood pressure can lead to a range of health problems, including cardiovascular disease and kidney disease. Patients need to monitor their blood pressure regularly while taking Selpercatinib and adjust their medication according to their doctor's recommendations.

Rash

The rash is one of the more common adverse effects of Selpercatinib and can cause skin irritation and itching. To alleviate these symptoms, patients should keep their skin clean and moisturized, avoid exposure to the sun, and avoid harsh cosmetics or toiletries.

Diarrhea

Some patients may experience diarrhea symptoms when taking Selpercatinib, which can lead to dehydration and electrolyte imbalances, and patients should inform their doctor if diarrhea is severe or lasts for a long time.

Hepatotoxicity

Serious hepatic adverse reactions occurred in 2.6% of patients treated with Selpercatinib. Before starting to take this medicine and during treatment, patients should regularly monitor liver function indicators, such as AST and ALT. If liver function is abnormal, your doctor may reduce the dose, stop the drug, or start other treatments, depending on the severity.

Prolongation of the QT interval

Prolonged QT interval can lead to serious consequences such as arrhythmias and cardiac arrest. Before and during treatment with Selpercatinib, the physician should assess whether the patient is at risk for QT prolongation and take appropriate precautions.

Hemorrhagic events

Selpercatinib may cause serious and fatal bleeding events, and patients should pay close attention to any unexplained bleeding symptoms during the use of this drug and seek medical attention immediately.

Adverse effects of Selpercatinib may involve multiple systems and organs, and their severity varies by individual differences. In order to ensure the safety and efficacy of patients, doctors and patients should pay attention to and properly manage these adverse effects.