Amifampridine is a potassium channel blocker, mainly used to treat Lambert-Eaton myasthenic syndrome (LEMS). The original drug was developed by BioMarin, USA. Patients need to obtain it through specific channels.

How to buy Amifampridine

Amifampridine has not yet been approved for marketing in China and is not included in the medical insurance catalog. Patients need to rely on international channels to obtain drugs, but they need to pay attention to the quality and legality of the drugs.

Purchase channels and precautions

Patients can purchase it through regular medical service institutions or international pharmacies. Since there are no generic drugs on the market, the original drugs need to be imported. When purchasing, you should verify the production date, batch number and anti-counterfeiting mark on the drug packaging to avoid purchasing expired or counterfeit products. It is recommended to give priority to qualified medical institutions or pharmacies, and require proof of drug import license.

Price and specification information

The original drug specification of Amifampridine produced by BioMarin, USA is 10mg*100 tablets, and the price of a single box is about US$3270. Prices may vary due to exchange rate fluctuations or transportation costs, for reference only. For patients who need long-term medication, it is recommended to plan the purchase cycle in advance and negotiate with medical institutions for a stable supply channel.

The purchase of Amifampridine should take into account both legality and safety. Obtaining drugs through reliable channels and strictly checking drug information are important prerequisites for maintaining the treatment effect.

Special population medication for Amifampridine

Different patient groups have different metabolism and tolerance to Amifampridine, and the medication regimen needs to be adjusted according to individual conditions.

Medication safety for pregnant and lactating women

Currently, there is a lack of safety data on the use of Amifampridine by pregnant women, and the pros and cons of treatment should be weighed during pregnancy. Lactating women should also be cautious because it is not clear whether the drug is secreted through breast milk. If medication is necessary, it is recommended to suspend breastfeeding or closely monitor the baby's reaction under the guidance of a doctor.

Dose adjustment for children and elderly patients

Amifampridine is suitable for children aged 6 years and above. The initial dose for children and adults weighing ≥45kg is 15mg per day, and for children weighing <45kg, it is 5mg per day. Due to the decline in physiological function, it is recommended to start with a low dose and strengthen adverse reaction monitoring for elderly patients. Patients with renal or hepatic insufficiency need to further reduce the dose to avoid the risk of drug accumulation.

Individualized evaluation is required for medication in special populations. Doctors should develop personalized plans based on the patient's age, weight and health status to avoid medication risks.

Contraindicated foods for Amifampridine

The efficacy of Amifampridine may be affected by drug or food interactions, and patients need to pay attention to the combination of diet and medication.

Interaction with drugs that lower the threshold for disease onset

Amifampridine may increase the risk of disease onset. If used in combination with other drugs that lower the threshold for disease onset (such as antidepressants and antipsychotics), neurological symptoms need to be strictly monitored. It is recommended to avoid using such drugs at the same time or adjust the dose under the guidance of a doctor.

Risks of cholinergic drugs

Drugs with cholinergic effects (such as cholinesterase inhibitors) may enhance the side effects of Amifampridine, including abdominal pain, nausea, etc. Patients should avoid taking health products or drugs containing cholinergic ingredients at the same time. If necessary, the medication time should be spaced and the treatment plan should be adjusted under the guidance of a doctor.

Reasonable avoidance of drug-food interactions is the key to improving the efficacy of amitraz. Patients need to actively inform their doctors of their current medications and follow their doctors' advice to adjust their daily diet.