Agamree (Vamorolone) is a drug used for the treatment of Duchenne Muscular Dystrophy (DMD), and various precautions need to be taken during its use. This article will elaborate in detail on the precautions for Agamree administration, dietary precautions, and medication for special populations. Long-term use of glucocorticoid drugs may lead to hypothalamic-pituitary-adrenal (HPA) axis suppression.

Precautions for Agamree Administration

Standardized use of Agamree is crucial for ensuring its therapeutic effect.

Abnormal Endocrine Function

Long-term use of glucocorticoid drugs, including Agamree, may cause suppression of the hypothalamic-pituitary-adrenal (HPA) axis, which in turn can lead to Cushing's syndrome, diabetes mellitus, and adrenal insufficiency. During the use of Agamree, patients' endocrine function should be closely monitored. Particularly when discontinuing the drug, the dosage must be gradually reduced to avoid adrenal insufficiency caused by sudden withdrawal.

Immunosuppression and Infection Risk

As a glucocorticoid drug, Agamree has immunosuppressive effects, which may increase the risk of new infections, reactivation of latent infections, and exacerbation of existing infections. Once signs of infection appear, patients should seek medical attention promptly, and consideration should be given to adjusting the dosage or discontinuing the drug.

Dietary Precautions for Agamree Use

Reasonable dietary coordination helps optimize the therapeutic effect and reduce adverse reactions.

Taking with Meals

The recommended regular dosage of Agamree is 6mg/kg orally once a day, preferably taken with meals. For patients weighing more than 50kg, the maximum daily dosage is 300mg.

Avoiding Specific Foods

Although the package insert of Agamree does not explicitly list foods that need to be avoided, glucocorticoid drugs may generally affect blood glucose levels. During the use of Agamree, patients should try to avoid high-sugar and high-fat foods to reduce the risk of blood glucose fluctuations. Maintaining a balanced diet and consuming sufficient protein, vitamins, and minerals is beneficial for maintaining overall health.

Agamree Medication for Special Populations

When using Agamree, individualized assessment should be conducted based on the patient's age and specific conditions.

Pregnant Women

Although Agamree is mainly used for the treatment of Duchenne Muscular Dystrophy in young males, the use of glucocorticoids during pregnancy should only be considered when the potential benefits outweigh the risks. Maternal use of high-dose glucocorticoids may increase the risk of adverse developmental outcomes in newborns, such as low birth weight and orofacial clefts.

Children and the Elderly

The safety and efficacy of Agamree in children aged 2 years and above have been verified through multi-center studies. Since Duchenne Muscular Dystrophy primarily affects children and adolescents, there is a lack of experience in using Agamree in elderly patients at this stage. Therefore, the safety and efficacy of Agamree in elderly patients have not yet been confirmed.

By strictly adhering to the precautions for drug administration, reasonably adjusting the dietary structure, and conducting individualized medication assessments for special populations, the therapeutic effect of Agamree can be maximized, and the occurrence of adverse reactions can be minimized.