Agamree is the first and only Duchenne Muscular Dystrophy (DMD) drug product to receive full approval in the European Union. Its launch in Germany, the United States, and the United Kingdom has brought new hope to numerous patients. However, it has not been launched in China and is not included in China's medical insurance system. For domestic patients, how to purchase this drug has become a key focus of attention. So, how can Agamree be purchased?

How to Purchase Agamree

Since Agamree has not yet been launched in China, domestic patients cannot buy it directly through hospitals or pharmacies. But there is no need to be overly concerned—here are some feasible purchasing channels:

Overseas Drug Purchase

Patients can purchase Agamree through formal overseas medical institutions or pharmacies. These institutions usually provide official invoices for the drugs, logistics tracking, and after-sales services, ensuring that the drugs patients receive are genuine. Overseas drug purchases may involve issues such as cross-border logistics and customs duties, so patients need to make relevant preparations in advance.

Participation in Clinical Trials

Another potential channel is to participate in Agamree's clinical trials. Pharmaceutical companies often conduct global clinical trials to evaluate the safety and efficacy of drugs. Patients can learn about and apply to participate in Agamree's clinical trials by following the official websites of relevant medical institutions or clinical trial registration platforms.

Side Effects of Agamree

Although Agamree has brought new therapeutic hope to DMD patients, the potential side effects during drug use cannot be ignored.

Cushingoid-like Changes

Long-term use of Agamree may lead to Cushingoid-like changes such as moon face (rounded face), hirsutism (excessive hair growth), and fragile skin. These changes may affect patients' appearance and mental health, so close attention is required during use.

Psychiatric and Behavioral Disorders

Some patients may experience psychiatric and behavioral disorders such as mood swings, insomnia, restlessness, or even depression after using Agamree. These side effects may have a negative impact on patients' daily lives and social abilities, so timely detection and intervention are necessary.

Dosage and Administration of Agamree

The correct use of Agamree is crucial for ensuring its therapeutic effect and reducing side effects.

Routine Dosage and Administration Route

The routine dosage of Agamree is 6 mg/kg once daily (the maximum daily dose is 300 mg for patients with a body weight exceeding 50 kg). The drug should be taken with meals to improve absorption. Before administration, the oral suspension should be shaken well for approximately 30 seconds, and the provided oral syringe should be used for dosing.

Discontinuation and Dosage Tapering

If Agamree is used continuously for more than one week, the dosage must be gradually reduced to lower the risk of adrenal insufficiency caused by sudden discontinuation. During the discontinuation process, patients should closely monitor their physical condition and reduce the dosage under the guidance of a doctor.

During the purchase and use of Agamree, it is essential to follow professional medical advice to ensure the safety and effectiveness of the drug.