Ivosidenib is a therapeutic drug for acute myeloid leukemia (AML) with specific gene mutations. Its price and efficacy have equally attracted the attention of patients. This article will delve into the price per tablet of Ivosidenib, while also analyzing in detail its contraindications and medication guidelines for special populations, to help patients gain a more comprehensive understanding of this drug.

How Much Does One Tablet of Ivosidenib Cost?

The price of Ivosidenib varies by brand and region. However, in general, it is an imported special drug with a relatively high price.

Price Details

Common brands of Ivosidenib available on the market currently include Laos Lucius and Bangladesh Everest, both with a specification of 250mg*60 tablets. The price of the Laos Lucius brand is approximately 604 US dollars per box, and this price is for reference only.

Factors Affecting the Price

The price of Ivosidenib is influenced by a variety of factors, including but not limited to raw material costs, production processes, brand premium, and market supply and demand. In addition, pricing strategies in different countries and regions can also lead to price differences. Patients can compare prices from different channels, and make a reasonable choice based on their personal economic conditions and medication needs.

Given the high price of Ivosidenib, patients should choose carefully when purchasing. It is recommended to buy through regular hospitals, online pharmacies, or officially authorized medical service institutions to avoid purchasing counterfeit or shoddy products. At the same time, patients can pay attention to relevant medical assistance programs or charity funds to reduce their economic burden.

Contraindications of Ivosidenib

Although Ivosidenib is an effective therapeutic drug, it is not suitable for all patients. Understanding and mastering its contraindications is important for ensuring medication safety.

Risk of Differentiation Syndrome

Differentiation syndrome may occur during treatment with Ivosidenib. This is a serious adverse reaction related to the rapid proliferation and differentiation of bone marrow cells, which may be life-threatening. Patients at risk of differentiation syndrome should use Ivosidenib with caution and closely monitor relevant symptoms during medication.

QTc Interval Prolongation

Ivosidenib may also cause prolongation of the QTc interval, increasing the risk of ventricular arrhythmias. The risk is even higher, especially when used in combination with drugs known to prolong the QTc interval.

Therefore, before medication, it is necessary to evaluate the patient's electrocardiogram (ECG) and electrolyte levels, conduct regular monitoring during medication, and adjust the dose or discontinue the drug if necessary.

Medication for Special Populations of Ivosidenib

For different special populations, the use of Ivosidenib requires special caution to ensure the safety and effectiveness of medication.

Pregnant and Lactating Women

Ivosidenib may cause harm to the fetus, so pregnant women should avoid using it. At the same time, it is recommended that lactating women stop breastfeeding during medication and for at least one month after discontinuing the drug, to prevent the drug from affecting the health of infants through breast milk.

Elderly Patients and Pediatric Patients

When elderly patients use Ivosidenib, no dose adjustment is required, but their liver and kidney functions as well as drug reactions should be closely monitored. For pediatric patients, relevant research data is currently lacking, so the use of Ivosidenib in patients under 18 years of age is not recommended.

Patients with Hepatic or Renal Impairment

For patients with mild or moderate hepatic or renal impairment, no adjustment to the starting dose of Ivosidenib is needed. However, the pharmacokinetics and safety of Ivosidenib in patients with severe hepatic or renal impairment are not yet clear. Therefore, the risks and benefits should be fully evaluated before medication.

During the medication period, patients should strictly follow the doctor's advice, conduct regular monitoring of relevant indicators, and ensure the safety and effectiveness of medication. At the same time, they should pay attention to the drug price and purchasing channels to reduce the economic burden and make the treatment process smoother.