Ezetimibe (Zetia) is an oral lipid-lowering medication primarily used to reduce low-density lipoprotein cholesterol (LDL-C) and other lipid levels in the blood. It works by inhibiting the absorption of cholesterol in the small intestine, and is often used in combination with statins or other lipid-lowering drugs to enhance the lipid-lowering effect.

Indications for Ezetimibe (Zetia)

Adult Primary Hyperlipidemia

Ezetimibe can be used in combination with statins, or alone when statins are not applicable.

As an adjunct to dietary control, it is used to reduce LDL-C levels in adults with primary hyperlipidemia (including heterozygous familial hypercholesterolemia, HeFH).

Pediatric Patients with HeFH

For pediatric patients with HeFH aged 10 years and older, ezetimibe can be used in combination with statins as an adjunct to dietary control to reduce elevated LDL-C levels.

Mixed Hyperlipidemia

Ezetimibe can be used in combination with fenofibrate for adults with mixed hyperlipidemia, as an adjunct to dietary control to reduce LDL-C.

Homozygous Familial Hypercholesterolemia (HoFH)

For adult and pediatric patients with HoFH aged 10 years and older, ezetimibe can be used in combination with statins and other lipid-lowering therapies to reduce elevated LDL-C levels.

Homozygous Familial Sitosterolemia

Ezetimibe can also be used as an adjunct to dietary control to reduce elevated sitosterol and campesterol levels caused by homozygous familial sitosterolemia in adults and pediatric patients aged 9 years and older.

Specifications and Properties of Ezetimibe (Zetia)

Specifications

Each ezetimibe tablet contains 10 mg of ezetimibe as the active ingredient.

This medication is an oral tablet, and each bottle is usually packaged with 30 tablets.

Properties

Ezetimibe tablets are white to off-white, capsule-shaped, and engraved with "414" on one side.

In addition to the active ingredient, the tablets contain the following excipients: croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.

Storage Method for Ezetimibe (Zetia)

Storage Temperature

Ezetimibe should be stored at room temperature, with a suitable temperature range of 20°C to 25°C (68°F to 77°F).

Avoid placing the medication in environments with excessively high or low temperatures, such as bathrooms, cars, or other places with large temperature fluctuations.

Moisture Protection

The tablets need to be kept dry and should be protected from moisture or humid environments.

It is recommended to keep the medicine bottle tightly closed and store it in the original packaging; do not transfer the tablets to other containers.

Other Precautions

Keep ezetimibe out of the reach of children to prevent accidental ingestion.

If the medication is expired or no longer needed, it should be discarded in accordance with local regulations; do not discard it randomly.