Raloxifene (Evista) is a selective estrogen receptor modulator (SERM) composed of raloxifene hydrochloride. Since its first approval in the United States in 1997, it has become an important medication for the treatment and prevention of postmenopausal osteoporosis.

Indications for Raloxifene (Evista)

Treatment and Prevention of Postmenopausal Osteoporosis

Raloxifene is indicated for the treatment and prevention of osteoporosis in postmenopausal women.

Clinical studies have shown that it can significantly increase bone mineral density and reduce the risk of vertebral fractures by 55%.

Reducing the Risk of Invasive Breast Cancer

Used to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis.

Used to reduce the risk of invasive breast cancer in postmenopausal women at high risk.

Clinical trials have shown that it can reduce the risk of estrogen receptor (ER)-positive breast cancer by 80%.

Important Usage Limitations

Not indicated for the treatment of invasive breast cancer.

Not indicated for reducing the risk of breast cancer recurrence.

Not indicated for reducing the risk of non-invasive breast cancer.

Specifications and Properties of Raloxifene (Evista)

Dosage Form and Content

60mg film-coated tablets, oval-shaped and white.

One side is imprinted with blue markings "4165" or "LILLY4165".

Physical Properties

Raloxifene hydrochloride is a white to off-white solid.

Molecular formula: C₂₈H₂₇NO₄S•HCl.

Molecular weight: 510.05 Daltons.

Extremely low solubility in water.

Excipient Ingredients

Tablet core: Anhydrous lactose, hypromellose, etc.

Film coating: Polyvinyl alcohol, titanium dioxide, etc.

Colorant: FD&C Blue No. 2 Aluminum Lake.

Packaging Specifications

30 tablets per bottle (unit packaging).

100 tablets per bottle (unit packaging).

2000 tablets per bottle.

Storage Methods for Raloxifene (Evista)

Temperature Requirements

Recommended storage temperature: 20-25°C (68-77°F).

Short-term exposure to an environment of 15-30°C (59-86°F) is allowed.

Packaging Requirements

Must be stored in the original packaging.

Protection from moisture and direct sunlight is required.

Keep out of the reach and sight of children.

Special Precautions

Tablets should remain intact and must not be crushed or chewed.

Expired medications should be disposed of in accordance with medical waste disposal regulations.

After opening the bottle, attention should be paid to moisture prevention.