Odevixibat (Bylvay) is an ileal bile acid transporter (IBAT) inhibitor, mainly indicated for the treatment of pruritus associated with progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome (ALGS). It is a prescription drug and must be used strictly in accordance with the doctor's instructions.

Indications for Odevixibat (Bylvay)

Purchase from Overseas

Patients may choose to consult and purchase odevixibat at hospital pharmacies or regular drugstores in countries or regions where the drug has been launched.

Since drug prices may be affected by factors such as regional differences and exchange rate fluctuations, patients need to make a budget and plan well before purchasing.

Purchase through Medical Service Institutions

Patients may consult domestic overseas medical service institutions that cooperate with international pharmacies or pharmaceutical companies.

These institutions can usually provide legal import channels and offer professional consultation and guidance.

Precautions for Purchasing Odevixibat (Bylvay)

Strictly Follow Medication Guidance

For PFIC patients (3 months of age and older): The initial dose is 40 mcg/kg per day, with a maximum dose not exceeding 120 mcg/kg per day.

For ALGS patients (12 months of age and older): The fixed dose is 120 mcg/kg per day.

Administration Method: The drug should be taken with breakfast in the morning. Capsules must not be chewed or crushed. For pediatric patients, oral granules can be mixed with soft food or liquids for administration.

Contraindications and High-Risk Populations

Contraindications: The drug is contraindicated in patients with decompensated liver function (e.g., hepatic encephalopathy, ascites, variceal bleeding).

Monitoring Requirements: Liver function (including ALT, AST, bilirubin, etc.) should be regularly tested before starting medication and during treatment, with close monitoring especially in the first 6-8 months.

Drug Interactions

Concurrent use with bile acid sequestrants (e.g., cholestyramine) should be avoided; an interval of at least 4 hours is required between their administrations.

How to Distinguish Genuine Odevixibat (Bylvay) from Counterfeits

Specification Markings

1.Oral Granules:

200 mcg: Ivory-colored capsules imprinted with "A200".

600 mcg: Ivory-colored capsules imprinted with "A600".

2.Capsules:

400 mcg: Orange-and-white capsules imprinted with "A400".

1200 mcg: Orange-colored capsules imprinted with "A1200".