Tacrolimus Capsules (Astagraf XL) are key immunosuppressants for preventing organ rejection after kidney transplantation. The safety of their use and risk management are directly related to patients' quality of life and the long-term function of transplanted organs.

What Are the Side Effects of Tacrolimus Capsules (Astagraf XL)?

Spectrum of Common Side Effects

Digestive system: Diarrhea (45%), constipation (40%), nausea (36%), vomiting (25%).

Fluid and electrolyte metabolism disorders: Peripheral edema (36%), hypertension (28%), hyperkalemia (20%).

Nervous system: Tremor (35%), headache (22%), insomnia (24%).

Hematological system: Anemia (33%), leukopenia (16%).

Abnormal laboratory indicators: Hypomagnesemia (24%), hypophosphatemia (23%), increased serum creatinine (19%), hyperglycemia (16%).

Severe Adverse Reactions Requiring High Alert for Tacrolimus Capsules (Astagraf XL)

Increased Risk of Malignant Tumors

Patients receiving treatment with immunosuppressants (including tacrolimus) have a significantly increased risk of developing lymphoma and other malignant tumors (especially skin cancer).

This risk is associated with the intensity and duration of immunosuppression, rather than being caused by a specific drug.

Life-Threatening Severe Infections

Cytomegalovirus (CMV) infection: The risk is highest when CMV-seronegative recipients receive organs from CMV-seropositive donors.

BK virus-associated polyomavirus nephropathy.

JC virus-associated progressive multifocal leukoencephalopathy (PML).

Organ-Specific Toxic Reactions

Nephrotoxicity: Acute or chronic kidney injury may occur, and the risk is compounded especially when used in combination with nephrotoxic drugs (such as aminoglycosides, ganciclovir, amphotericin B, etc.).

Precautions for Using Tacrolimus Capsules (Astagraf XL)

Strictly Follow the Administration Regimen

The capsules must be swallowed whole; do not chew, crush, or dissolve them.

Take the medication on an empty stomach at a fixed time every morning (1 hour before a meal or 2 hours after a meal).

If a dose is missed, take the missed dose within 14 hours (for example, if the scheduled dose is at 8:00 a.m., it can be delayed until 10:00 p.m. at the latest). If more than 14 hours have passed, skip the missed dose and take the regular dose the next morning; doubling the dose is strictly prohibited.

Close Therapeutic Drug Concentration Monitoring

During the initial stage of treatment, monitor the whole-blood trough concentration at least twice a week.

Increase the monitoring frequency when the dose is adjusted, the combined medications are changed, or liver and kidney function changes.

List of Substances Contraindicated for Concurrent Use

Grapefruit and its products: May cause an abnormal increase in tacrolimus blood concentration.

Alcoholic beverages: May increase the rate of drug release.

Live vaccine vaccination: Live vaccines such as measles, mumps, rubella, and oral polio vaccines are prohibited during treatment.