Before taking this medicine

Key precautions include osteosarcoma risk, hypercalcemia, urolithiasis, orthostatic hypotension, and drug interactions; contraindications include pediatric use and hypersensitivity.  

Precautions and Contraindications  

Teriparatide is contraindicated in patients with hypersensitivity reactions (e.g., anaphylaxis) or conditions predisposing to osteosarcoma (Paget’s disease, prior skeletal radiation, bone metastases). Avoid use in hypercalcemic disorders (e.g., hyperparathyroidism) and pediatric patients (open epiphyses). Monitor for transient hypercalcemia (peak 4–6 hours post-dose) and urolithiasis; adjust calcium supplements if serum calcium exceeds 10.6 mg/dL. Orthostatic hypotension may occur within 4 hours of initial doses. Concomitant digoxin requires monitoring due to hypercalcemia-induced toxicity risks. Pregnancy and lactation are contraindicated due to insufficient safety data.